Pathogenesis and Transmissibility of North American Highly Pathogenic Avian Influenza A(H5N1) Virus in Ferrets

Highly pathogenic avian influenza A(H5N1) viruses have spread rapidly throughout North American flyways in recent months, affecting wild birds in over 40 states. We evaluated the pathogenicity and transmissibility of a representative virus using a ferret model and examined replication kinetics of th...

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Autores principales: Pulit-Penaloza, Joanna A., Belser, Jessica A., Brock, Nicole, Thakur, Poulami Basu, Tumpey, Terrence M., Maines, Taronna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423912/
https://www.ncbi.nlm.nih.gov/pubmed/35840125
http://dx.doi.org/10.3201/eid2809.220879
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author Pulit-Penaloza, Joanna A.
Belser, Jessica A.
Brock, Nicole
Thakur, Poulami Basu
Tumpey, Terrence M.
Maines, Taronna R.
author_facet Pulit-Penaloza, Joanna A.
Belser, Jessica A.
Brock, Nicole
Thakur, Poulami Basu
Tumpey, Terrence M.
Maines, Taronna R.
author_sort Pulit-Penaloza, Joanna A.
collection PubMed
description Highly pathogenic avian influenza A(H5N1) viruses have spread rapidly throughout North American flyways in recent months, affecting wild birds in over 40 states. We evaluated the pathogenicity and transmissibility of a representative virus using a ferret model and examined replication kinetics of this virus in human respiratory tract cells.
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spelling pubmed-94239122022-09-07 Pathogenesis and Transmissibility of North American Highly Pathogenic Avian Influenza A(H5N1) Virus in Ferrets Pulit-Penaloza, Joanna A. Belser, Jessica A. Brock, Nicole Thakur, Poulami Basu Tumpey, Terrence M. Maines, Taronna R. Emerg Infect Dis Research Letter Highly pathogenic avian influenza A(H5N1) viruses have spread rapidly throughout North American flyways in recent months, affecting wild birds in over 40 states. We evaluated the pathogenicity and transmissibility of a representative virus using a ferret model and examined replication kinetics of this virus in human respiratory tract cells. Centers for Disease Control and Prevention 2022-09 /pmc/articles/PMC9423912/ /pubmed/35840125 http://dx.doi.org/10.3201/eid2809.220879 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Pulit-Penaloza, Joanna A.
Belser, Jessica A.
Brock, Nicole
Thakur, Poulami Basu
Tumpey, Terrence M.
Maines, Taronna R.
Pathogenesis and Transmissibility of North American Highly Pathogenic Avian Influenza A(H5N1) Virus in Ferrets
title Pathogenesis and Transmissibility of North American Highly Pathogenic Avian Influenza A(H5N1) Virus in Ferrets
title_full Pathogenesis and Transmissibility of North American Highly Pathogenic Avian Influenza A(H5N1) Virus in Ferrets
title_fullStr Pathogenesis and Transmissibility of North American Highly Pathogenic Avian Influenza A(H5N1) Virus in Ferrets
title_full_unstemmed Pathogenesis and Transmissibility of North American Highly Pathogenic Avian Influenza A(H5N1) Virus in Ferrets
title_short Pathogenesis and Transmissibility of North American Highly Pathogenic Avian Influenza A(H5N1) Virus in Ferrets
title_sort pathogenesis and transmissibility of north american highly pathogenic avian influenza a(h5n1) virus in ferrets
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423912/
https://www.ncbi.nlm.nih.gov/pubmed/35840125
http://dx.doi.org/10.3201/eid2809.220879
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