Longitudinal SARS-CoV-2 Nucleocapsid Antibody Kinetics, Seroreversion, and Implications for Seroepidemiologic Studies

Given widespread use of spike antibody in generating coronavirus disease vaccines, SARS-CoV-2 nucleocapsid antibodies are increasingly used to indicate previous infection in serologic surveys. However, longitudinal kinetics and seroreversion are poorly defined. We found substantial seroreversion of...

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Detalles Bibliográficos
Autores principales: Loesche, Michael, Karlson, Elizabeth W., Talabi, Opeyemi, Zhou, Guohai, Boutin, Natalie, Atchley, Rachel, Loevinsohn, Gideon, Chang, Jun Bai Park, Hasdianda, Mohammad A., Okenla, Adetoun, Sampson, Elizabeth, Schram, Haley, Magsipoc, Karen, Goodman, Kirsten, Donahue, Lauren, MacGowan, Maureen, Novack, Lewis A., Jarolim, Petr, Baden, Lindsey R., Nilles, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423917/
https://www.ncbi.nlm.nih.gov/pubmed/35868337
http://dx.doi.org/10.3201/eid2809.220729
Descripción
Sumario:Given widespread use of spike antibody in generating coronavirus disease vaccines, SARS-CoV-2 nucleocapsid antibodies are increasingly used to indicate previous infection in serologic surveys. However, longitudinal kinetics and seroreversion are poorly defined. We found substantial seroreversion of nucleocapsid total immunoglobulin, underscoring the need to account for seroreversion in seroepidemiologic studies.

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