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Longitudinal SARS-CoV-2 Nucleocapsid Antibody Kinetics, Seroreversion, and Implications for Seroepidemiologic Studies
Given widespread use of spike antibody in generating coronavirus disease vaccines, SARS-CoV-2 nucleocapsid antibodies are increasingly used to indicate previous infection in serologic surveys. However, longitudinal kinetics and seroreversion are poorly defined. We found substantial seroreversion of...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Centers for Disease Control and Prevention
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423917/ https://www.ncbi.nlm.nih.gov/pubmed/35868337 http://dx.doi.org/10.3201/eid2809.220729 |
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| author | Loesche, Michael Karlson, Elizabeth W. Talabi, Opeyemi Zhou, Guohai Boutin, Natalie Atchley, Rachel Loevinsohn, Gideon Chang, Jun Bai Park Hasdianda, Mohammad A. Okenla, Adetoun Sampson, Elizabeth Schram, Haley Magsipoc, Karen Goodman, Kirsten Donahue, Lauren MacGowan, Maureen Novack, Lewis A. Jarolim, Petr Baden, Lindsey R. Nilles, Eric J. |
| author_facet | Loesche, Michael Karlson, Elizabeth W. Talabi, Opeyemi Zhou, Guohai Boutin, Natalie Atchley, Rachel Loevinsohn, Gideon Chang, Jun Bai Park Hasdianda, Mohammad A. Okenla, Adetoun Sampson, Elizabeth Schram, Haley Magsipoc, Karen Goodman, Kirsten Donahue, Lauren MacGowan, Maureen Novack, Lewis A. Jarolim, Petr Baden, Lindsey R. Nilles, Eric J. |
| author_sort | Loesche, Michael |
| collection | PubMed |
| description | Given widespread use of spike antibody in generating coronavirus disease vaccines, SARS-CoV-2 nucleocapsid antibodies are increasingly used to indicate previous infection in serologic surveys. However, longitudinal kinetics and seroreversion are poorly defined. We found substantial seroreversion of nucleocapsid total immunoglobulin, underscoring the need to account for seroreversion in seroepidemiologic studies. |
| format | Online Article Text |
| id | pubmed-9423917 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Centers for Disease Control and Prevention |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-94239172022-09-07 Longitudinal SARS-CoV-2 Nucleocapsid Antibody Kinetics, Seroreversion, and Implications for Seroepidemiologic Studies Loesche, Michael Karlson, Elizabeth W. Talabi, Opeyemi Zhou, Guohai Boutin, Natalie Atchley, Rachel Loevinsohn, Gideon Chang, Jun Bai Park Hasdianda, Mohammad A. Okenla, Adetoun Sampson, Elizabeth Schram, Haley Magsipoc, Karen Goodman, Kirsten Donahue, Lauren MacGowan, Maureen Novack, Lewis A. Jarolim, Petr Baden, Lindsey R. Nilles, Eric J. Emerg Infect Dis Dispatch Given widespread use of spike antibody in generating coronavirus disease vaccines, SARS-CoV-2 nucleocapsid antibodies are increasingly used to indicate previous infection in serologic surveys. However, longitudinal kinetics and seroreversion are poorly defined. We found substantial seroreversion of nucleocapsid total immunoglobulin, underscoring the need to account for seroreversion in seroepidemiologic studies. Centers for Disease Control and Prevention 2022-09 /pmc/articles/PMC9423917/ /pubmed/35868337 http://dx.doi.org/10.3201/eid2809.220729 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
| spellingShingle | Dispatch Loesche, Michael Karlson, Elizabeth W. Talabi, Opeyemi Zhou, Guohai Boutin, Natalie Atchley, Rachel Loevinsohn, Gideon Chang, Jun Bai Park Hasdianda, Mohammad A. Okenla, Adetoun Sampson, Elizabeth Schram, Haley Magsipoc, Karen Goodman, Kirsten Donahue, Lauren MacGowan, Maureen Novack, Lewis A. Jarolim, Petr Baden, Lindsey R. Nilles, Eric J. Longitudinal SARS-CoV-2 Nucleocapsid Antibody Kinetics, Seroreversion, and Implications for Seroepidemiologic Studies |
| title | Longitudinal SARS-CoV-2 Nucleocapsid Antibody Kinetics, Seroreversion, and Implications for Seroepidemiologic Studies |
| title_full | Longitudinal SARS-CoV-2 Nucleocapsid Antibody Kinetics, Seroreversion, and Implications for Seroepidemiologic Studies |
| title_fullStr | Longitudinal SARS-CoV-2 Nucleocapsid Antibody Kinetics, Seroreversion, and Implications for Seroepidemiologic Studies |
| title_full_unstemmed | Longitudinal SARS-CoV-2 Nucleocapsid Antibody Kinetics, Seroreversion, and Implications for Seroepidemiologic Studies |
| title_short | Longitudinal SARS-CoV-2 Nucleocapsid Antibody Kinetics, Seroreversion, and Implications for Seroepidemiologic Studies |
| title_sort | longitudinal sars-cov-2 nucleocapsid antibody kinetics, seroreversion, and implications for seroepidemiologic studies |
| topic | Dispatch |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423917/ https://www.ncbi.nlm.nih.gov/pubmed/35868337 http://dx.doi.org/10.3201/eid2809.220729 |
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