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Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision
A spinal cord injury (SCI) occurs when the spinal cord is deteriorated or traumatized, leading to motor and sensory functions lost even totally or partially. An imbalance within the generation of reactive oxygen species and antioxidant defense levels results in oxidative stress (OS) and neuroinflamm...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423984/ https://www.ncbi.nlm.nih.gov/pubmed/36046682 http://dx.doi.org/10.1155/2022/8741787 |
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author | Islam, Fahadul Bepary, Sristy Nafady, Mohamed H. Islam, Md. Rezaul Emran, Talha Bin Sultana, Sharifa Huq, Md. Amdadul Mitra, Saikat Chopra, Hitesh Sharma, Rohit Sweilam, Sherouk Hussein Khandaker, Mayeen Uddin Idris, Abubakr M. |
author_facet | Islam, Fahadul Bepary, Sristy Nafady, Mohamed H. Islam, Md. Rezaul Emran, Talha Bin Sultana, Sharifa Huq, Md. Amdadul Mitra, Saikat Chopra, Hitesh Sharma, Rohit Sweilam, Sherouk Hussein Khandaker, Mayeen Uddin Idris, Abubakr M. |
author_sort | Islam, Fahadul |
collection | PubMed |
description | A spinal cord injury (SCI) occurs when the spinal cord is deteriorated or traumatized, leading to motor and sensory functions lost even totally or partially. An imbalance within the generation of reactive oxygen species and antioxidant defense levels results in oxidative stress (OS) and neuroinflammation. After SCI, OS and occurring pathways of inflammations are significant strenuous drivers of cross-linked dysregulated pathways. It emphasizes the significance of multitarget therapy in combating SCI consequences. Polyphenols, which are secondary metabolites originating from plants, have the promise to be used as alternative therapeutic agents to treat SCI. Secondary metabolites have activity on neuroinflammatory, neuronal OS, and extrinsic axonal dysregulated pathways during the early stages of SCI. Experimental and clinical investigations have noted the possible importance of phenolic compounds as important phytochemicals in moderating upstream dysregulated OS/inflammatory signaling mediators and axonal regeneration's extrinsic pathways after the SCI probable significance of phenolic compounds as important phytochemicals in mediating upstream dysregulated OS/inflammatory signaling mediators. Furthermore, combining polyphenols could be a way to lessen the effects of SCI. |
format | Online Article Text |
id | pubmed-9423984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-94239842022-08-30 Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision Islam, Fahadul Bepary, Sristy Nafady, Mohamed H. Islam, Md. Rezaul Emran, Talha Bin Sultana, Sharifa Huq, Md. Amdadul Mitra, Saikat Chopra, Hitesh Sharma, Rohit Sweilam, Sherouk Hussein Khandaker, Mayeen Uddin Idris, Abubakr M. Oxid Med Cell Longev Review Article A spinal cord injury (SCI) occurs when the spinal cord is deteriorated or traumatized, leading to motor and sensory functions lost even totally or partially. An imbalance within the generation of reactive oxygen species and antioxidant defense levels results in oxidative stress (OS) and neuroinflammation. After SCI, OS and occurring pathways of inflammations are significant strenuous drivers of cross-linked dysregulated pathways. It emphasizes the significance of multitarget therapy in combating SCI consequences. Polyphenols, which are secondary metabolites originating from plants, have the promise to be used as alternative therapeutic agents to treat SCI. Secondary metabolites have activity on neuroinflammatory, neuronal OS, and extrinsic axonal dysregulated pathways during the early stages of SCI. Experimental and clinical investigations have noted the possible importance of phenolic compounds as important phytochemicals in moderating upstream dysregulated OS/inflammatory signaling mediators and axonal regeneration's extrinsic pathways after the SCI probable significance of phenolic compounds as important phytochemicals in mediating upstream dysregulated OS/inflammatory signaling mediators. Furthermore, combining polyphenols could be a way to lessen the effects of SCI. Hindawi 2022-08-22 /pmc/articles/PMC9423984/ /pubmed/36046682 http://dx.doi.org/10.1155/2022/8741787 Text en Copyright © 2022 Fahadul Islam et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Islam, Fahadul Bepary, Sristy Nafady, Mohamed H. Islam, Md. Rezaul Emran, Talha Bin Sultana, Sharifa Huq, Md. Amdadul Mitra, Saikat Chopra, Hitesh Sharma, Rohit Sweilam, Sherouk Hussein Khandaker, Mayeen Uddin Idris, Abubakr M. Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision |
title | Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision |
title_full | Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision |
title_fullStr | Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision |
title_full_unstemmed | Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision |
title_short | Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision |
title_sort | polyphenols targeting oxidative stress in spinal cord injury: current status and future vision |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423984/ https://www.ncbi.nlm.nih.gov/pubmed/36046682 http://dx.doi.org/10.1155/2022/8741787 |
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