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Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis

Although substantial progress has been made in the immunotherapy of kidney cancer, its efficacy varies from patient to patient, with many responding suboptimally or even developing metastases. Thus, research on the tumour immune microenvironment and immune cell heterogeneity is essential for kidney...

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Autores principales: Liang, Zhengfang, Nong, Fengwei, Zhao, Jingjie, Wei, Dalong, Tang, Qianli, Song, Jian, Meng, Lingzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424044/
https://www.ncbi.nlm.nih.gov/pubmed/36046723
http://dx.doi.org/10.1155/2022/6378567
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author Liang, Zhengfang
Nong, Fengwei
Zhao, Jingjie
Wei, Dalong
Tang, Qianli
Song, Jian
Meng, Lingzhang
author_facet Liang, Zhengfang
Nong, Fengwei
Zhao, Jingjie
Wei, Dalong
Tang, Qianli
Song, Jian
Meng, Lingzhang
author_sort Liang, Zhengfang
collection PubMed
description Although substantial progress has been made in the immunotherapy of kidney cancer, its efficacy varies from patient to patient, with many responding suboptimally or even developing metastases. Thus, research on the tumour immune microenvironment and immune cell heterogeneity is essential for kidney cancer treatment. In this study, natural killer (NK) cell populations were isolated using signature genes from the single-cell sequencing data of clear cell renal cell carcinoma (ccRCC) and normal kidney tissues and divided into three subpopulations according to the differences in gene expression profiles: NK(GZMH), NK(EGR1), and NK(CAPG). Gene set enrichment analysis revealed that NK(EGR1) and NK(CAPG) were closely related to tumour metastasis, as shown by kidney cancer metastasis to Hodgkin lymphoma, T-cell leukaemia, and Ki-1+ anaplastic large cell lymphoma. Thus, these two NK cell subpopulations are promising targets for inhibiting metastasis in ccRCC. Our findings revealed heterogeneity in the infiltrating NK cells of kidney cancer, which can serve as a reference for the mechanisms underlying metastasis in kidney cancer.
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spelling pubmed-94240442022-08-30 Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis Liang, Zhengfang Nong, Fengwei Zhao, Jingjie Wei, Dalong Tang, Qianli Song, Jian Meng, Lingzhang J Immunol Res Research Article Although substantial progress has been made in the immunotherapy of kidney cancer, its efficacy varies from patient to patient, with many responding suboptimally or even developing metastases. Thus, research on the tumour immune microenvironment and immune cell heterogeneity is essential for kidney cancer treatment. In this study, natural killer (NK) cell populations were isolated using signature genes from the single-cell sequencing data of clear cell renal cell carcinoma (ccRCC) and normal kidney tissues and divided into three subpopulations according to the differences in gene expression profiles: NK(GZMH), NK(EGR1), and NK(CAPG). Gene set enrichment analysis revealed that NK(EGR1) and NK(CAPG) were closely related to tumour metastasis, as shown by kidney cancer metastasis to Hodgkin lymphoma, T-cell leukaemia, and Ki-1+ anaplastic large cell lymphoma. Thus, these two NK cell subpopulations are promising targets for inhibiting metastasis in ccRCC. Our findings revealed heterogeneity in the infiltrating NK cells of kidney cancer, which can serve as a reference for the mechanisms underlying metastasis in kidney cancer. Hindawi 2022-08-22 /pmc/articles/PMC9424044/ /pubmed/36046723 http://dx.doi.org/10.1155/2022/6378567 Text en Copyright © 2022 Zhengfang Liang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liang, Zhengfang
Nong, Fengwei
Zhao, Jingjie
Wei, Dalong
Tang, Qianli
Song, Jian
Meng, Lingzhang
Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis
title Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis
title_full Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis
title_fullStr Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis
title_full_unstemmed Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis
title_short Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis
title_sort heterogeneity in nk cell subpopulations may be involved in kidney cancer metastasis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424044/
https://www.ncbi.nlm.nih.gov/pubmed/36046723
http://dx.doi.org/10.1155/2022/6378567
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