Metformin-associated Lactic Acidosis with Hypoglycemia during the COVID-19 Pandemic

Metformin-associated lactic acidosis (MALA) is an extremely rare but life-threatening adverse effect of metformin treatment. The lifestyle changes associated with the coronavirus disease 2019 (COVID-19) pandemic may increase the potential risk of MALA development in patients with diabetes. We herein...

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Autores principales: Takayama, Kana, Obata, Yoshinari, Maruo, Yumiko, Yamaguchi, Hiroki, Kosugi, Motohiro, Irie, Yoko, Hazama, Yoji, Yasuda, Tetsuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424080/
https://www.ncbi.nlm.nih.gov/pubmed/35598993
http://dx.doi.org/10.2169/internalmedicine.9179-21
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author Takayama, Kana
Obata, Yoshinari
Maruo, Yumiko
Yamaguchi, Hiroki
Kosugi, Motohiro
Irie, Yoko
Hazama, Yoji
Yasuda, Tetsuyuki
author_facet Takayama, Kana
Obata, Yoshinari
Maruo, Yumiko
Yamaguchi, Hiroki
Kosugi, Motohiro
Irie, Yoko
Hazama, Yoji
Yasuda, Tetsuyuki
author_sort Takayama, Kana
collection PubMed
description Metformin-associated lactic acidosis (MALA) is an extremely rare but life-threatening adverse effect of metformin treatment. The lifestyle changes associated with the coronavirus disease 2019 (COVID-19) pandemic may increase the potential risk of MALA development in patients with diabetes. We herein report a 64-year-old Japanese man taking a small dose of metformin who presented with MALA accompanied by hypoglycemia secondary to increased alcohol consumption triggered by lifestyle changes during the pandemic. Physicians should prescribe metformin judiciously to prevent MALA development and pay close attention to lifestyle changes in patients at risk for MALA during the COVID-19 pandemic.
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spelling pubmed-94240802022-09-15 Metformin-associated Lactic Acidosis with Hypoglycemia during the COVID-19 Pandemic Takayama, Kana Obata, Yoshinari Maruo, Yumiko Yamaguchi, Hiroki Kosugi, Motohiro Irie, Yoko Hazama, Yoji Yasuda, Tetsuyuki Intern Med Case Report Metformin-associated lactic acidosis (MALA) is an extremely rare but life-threatening adverse effect of metformin treatment. The lifestyle changes associated with the coronavirus disease 2019 (COVID-19) pandemic may increase the potential risk of MALA development in patients with diabetes. We herein report a 64-year-old Japanese man taking a small dose of metformin who presented with MALA accompanied by hypoglycemia secondary to increased alcohol consumption triggered by lifestyle changes during the pandemic. Physicians should prescribe metformin judiciously to prevent MALA development and pay close attention to lifestyle changes in patients at risk for MALA during the COVID-19 pandemic. The Japanese Society of Internal Medicine 2022-05-21 2022-08-01 /pmc/articles/PMC9424080/ /pubmed/35598993 http://dx.doi.org/10.2169/internalmedicine.9179-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Takayama, Kana
Obata, Yoshinari
Maruo, Yumiko
Yamaguchi, Hiroki
Kosugi, Motohiro
Irie, Yoko
Hazama, Yoji
Yasuda, Tetsuyuki
Metformin-associated Lactic Acidosis with Hypoglycemia during the COVID-19 Pandemic
title Metformin-associated Lactic Acidosis with Hypoglycemia during the COVID-19 Pandemic
title_full Metformin-associated Lactic Acidosis with Hypoglycemia during the COVID-19 Pandemic
title_fullStr Metformin-associated Lactic Acidosis with Hypoglycemia during the COVID-19 Pandemic
title_full_unstemmed Metformin-associated Lactic Acidosis with Hypoglycemia during the COVID-19 Pandemic
title_short Metformin-associated Lactic Acidosis with Hypoglycemia during the COVID-19 Pandemic
title_sort metformin-associated lactic acidosis with hypoglycemia during the covid-19 pandemic
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424080/
https://www.ncbi.nlm.nih.gov/pubmed/35598993
http://dx.doi.org/10.2169/internalmedicine.9179-21
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