Two Cases of Intraabdominal Bleeding Caused by Hepatocellular Carcinoma Rupture Soon after the Initiation of Chemotherapy with Lenvatinib

We herein report two patients with hepatocellular carcinoma (HCC) who exhibited intraabdominal bleeding caused by tumor rupture soon after lenvatinib initiation. A hypervascular nodule was present in the lateral segment manifesting extrahepatic protrusion in an 81-year-old-man and in the caudate lob...

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Autores principales: Sato, Aya, Imai, Yukinori, Uchiya, Hiroshi, Uchida, Yoshihito, Nakazawa, Manabu, Sugawara, Kayoko, Nakayama, Nobuaki, Mochida, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424085/
https://www.ncbi.nlm.nih.gov/pubmed/35283380
http://dx.doi.org/10.2169/internalmedicine.8733-21
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author Sato, Aya
Imai, Yukinori
Uchiya, Hiroshi
Uchida, Yoshihito
Nakazawa, Manabu
Sugawara, Kayoko
Nakayama, Nobuaki
Mochida, Satoshi
author_facet Sato, Aya
Imai, Yukinori
Uchiya, Hiroshi
Uchida, Yoshihito
Nakazawa, Manabu
Sugawara, Kayoko
Nakayama, Nobuaki
Mochida, Satoshi
author_sort Sato, Aya
collection PubMed
description We herein report two patients with hepatocellular carcinoma (HCC) who exhibited intraabdominal bleeding caused by tumor rupture soon after lenvatinib initiation. A hypervascular nodule was present in the lateral segment manifesting extrahepatic protrusion in an 81-year-old-man and in the caudate lobe, which was completely occupied by the tumor, in an 83-year-old-man. Both patients were given lenvatinib, and epigastralgia occurred suddenly three and five days later. Computed tomography revealed high-attenuation areas suggesting bleeding around the left and caudate lobes. Considering the strong antiangiogenic effects by lenvatinib, transcatheter arterial embolization should be performed before lenvatinib initiation in patients with subcapsular HCC.
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spelling pubmed-94240852022-09-15 Two Cases of Intraabdominal Bleeding Caused by Hepatocellular Carcinoma Rupture Soon after the Initiation of Chemotherapy with Lenvatinib Sato, Aya Imai, Yukinori Uchiya, Hiroshi Uchida, Yoshihito Nakazawa, Manabu Sugawara, Kayoko Nakayama, Nobuaki Mochida, Satoshi Intern Med Case Report We herein report two patients with hepatocellular carcinoma (HCC) who exhibited intraabdominal bleeding caused by tumor rupture soon after lenvatinib initiation. A hypervascular nodule was present in the lateral segment manifesting extrahepatic protrusion in an 81-year-old-man and in the caudate lobe, which was completely occupied by the tumor, in an 83-year-old-man. Both patients were given lenvatinib, and epigastralgia occurred suddenly three and five days later. Computed tomography revealed high-attenuation areas suggesting bleeding around the left and caudate lobes. Considering the strong antiangiogenic effects by lenvatinib, transcatheter arterial embolization should be performed before lenvatinib initiation in patients with subcapsular HCC. The Japanese Society of Internal Medicine 2022-03-12 2022-08-01 /pmc/articles/PMC9424085/ /pubmed/35283380 http://dx.doi.org/10.2169/internalmedicine.8733-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sato, Aya
Imai, Yukinori
Uchiya, Hiroshi
Uchida, Yoshihito
Nakazawa, Manabu
Sugawara, Kayoko
Nakayama, Nobuaki
Mochida, Satoshi
Two Cases of Intraabdominal Bleeding Caused by Hepatocellular Carcinoma Rupture Soon after the Initiation of Chemotherapy with Lenvatinib
title Two Cases of Intraabdominal Bleeding Caused by Hepatocellular Carcinoma Rupture Soon after the Initiation of Chemotherapy with Lenvatinib
title_full Two Cases of Intraabdominal Bleeding Caused by Hepatocellular Carcinoma Rupture Soon after the Initiation of Chemotherapy with Lenvatinib
title_fullStr Two Cases of Intraabdominal Bleeding Caused by Hepatocellular Carcinoma Rupture Soon after the Initiation of Chemotherapy with Lenvatinib
title_full_unstemmed Two Cases of Intraabdominal Bleeding Caused by Hepatocellular Carcinoma Rupture Soon after the Initiation of Chemotherapy with Lenvatinib
title_short Two Cases of Intraabdominal Bleeding Caused by Hepatocellular Carcinoma Rupture Soon after the Initiation of Chemotherapy with Lenvatinib
title_sort two cases of intraabdominal bleeding caused by hepatocellular carcinoma rupture soon after the initiation of chemotherapy with lenvatinib
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424085/
https://www.ncbi.nlm.nih.gov/pubmed/35283380
http://dx.doi.org/10.2169/internalmedicine.8733-21
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