Cumulative life course adversity, mental health, and cognition in the UK biobank

The association between adversity and cognition varies according to the specific adversity, when the adversity was experienced, and the cognitive domains investigated. Disentangling the effect of adversity and the underlying mechanistic pathway is therefore difficult. The association between adversi...

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Autores principales: Künzi, M., Gheorghe, D. A., Kliegel, M., Ballhausen, N., Gallacher, J., Bauermeister, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424182/
https://www.ncbi.nlm.nih.gov/pubmed/36038622
http://dx.doi.org/10.1038/s41598-022-18928-9
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author Künzi, M.
Gheorghe, D. A.
Kliegel, M.
Ballhausen, N.
Gallacher, J.
Bauermeister, S.
author_facet Künzi, M.
Gheorghe, D. A.
Kliegel, M.
Ballhausen, N.
Gallacher, J.
Bauermeister, S.
author_sort Künzi, M.
collection PubMed
description The association between adversity and cognition varies according to the specific adversity, when the adversity was experienced, and the cognitive domains investigated. Disentangling the effect of adversity and the underlying mechanistic pathway is therefore difficult. The association between adversity (i.e., maltreatment) accumulated over the life course and cognitive flexibility, as well as two potential mediators (i.e., intra-individual variability in reaction time and depression) of this association, were investigated. Data stem from the baseline population of the UK Biobank study (N = 73,489, Mdn(age) = 56, SD(age) = 7.628, 55.740% of women). Cumulative life course adversity (specifically maltreatment) was measured with items based on the Childhood Trauma Questionnaire (CTS-5) and items adapted from the British Crime Survey. Depression was assessed with the Patient Health Questionnaire-9 (PHQ-9). Intra-individual variability in reaction time was measured with a reaction time test “snap game” and the Trail Making Test A and B were used as a measure of cognitive flexibility. A path analysis was performed on these data. Higher cumulative adverse experiences were associated with lower performance in cognitive flexibility (β = .016, p < .001, 95% CI [0.009, 0.024]), and this effect was partly mediated by the level of depression (22.727% of the total effect of cumulative life course adversity on cognitive flexibility was mediated by depression (β = .005, p < .001, 95% CI [0.004, 0.007])). No association between cumulative life course adverse experiences and intra-individual variability in reaction time was found, nor was any indirect association between cumulative life course adversity and performance in cognitive flexibility via intra-individual variability in reaction time. The association between cumulative life course adversity, depression, and performance in cognitive flexibility has been highlighted. In contrast, no indirect effect between cumulative life course adversity and performance in cognitive flexibility via intra-individual variability in reaction time was found, suggesting that it is not a potential mechanism underlying the association between cumulative life course adversity and executive function.
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spelling pubmed-94241822022-08-31 Cumulative life course adversity, mental health, and cognition in the UK biobank Künzi, M. Gheorghe, D. A. Kliegel, M. Ballhausen, N. Gallacher, J. Bauermeister, S. Sci Rep Article The association between adversity and cognition varies according to the specific adversity, when the adversity was experienced, and the cognitive domains investigated. Disentangling the effect of adversity and the underlying mechanistic pathway is therefore difficult. The association between adversity (i.e., maltreatment) accumulated over the life course and cognitive flexibility, as well as two potential mediators (i.e., intra-individual variability in reaction time and depression) of this association, were investigated. Data stem from the baseline population of the UK Biobank study (N = 73,489, Mdn(age) = 56, SD(age) = 7.628, 55.740% of women). Cumulative life course adversity (specifically maltreatment) was measured with items based on the Childhood Trauma Questionnaire (CTS-5) and items adapted from the British Crime Survey. Depression was assessed with the Patient Health Questionnaire-9 (PHQ-9). Intra-individual variability in reaction time was measured with a reaction time test “snap game” and the Trail Making Test A and B were used as a measure of cognitive flexibility. A path analysis was performed on these data. Higher cumulative adverse experiences were associated with lower performance in cognitive flexibility (β = .016, p < .001, 95% CI [0.009, 0.024]), and this effect was partly mediated by the level of depression (22.727% of the total effect of cumulative life course adversity on cognitive flexibility was mediated by depression (β = .005, p < .001, 95% CI [0.004, 0.007])). No association between cumulative life course adverse experiences and intra-individual variability in reaction time was found, nor was any indirect association between cumulative life course adversity and performance in cognitive flexibility via intra-individual variability in reaction time. The association between cumulative life course adversity, depression, and performance in cognitive flexibility has been highlighted. In contrast, no indirect effect between cumulative life course adversity and performance in cognitive flexibility via intra-individual variability in reaction time was found, suggesting that it is not a potential mechanism underlying the association between cumulative life course adversity and executive function. Nature Publishing Group UK 2022-08-29 /pmc/articles/PMC9424182/ /pubmed/36038622 http://dx.doi.org/10.1038/s41598-022-18928-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Künzi, M.
Gheorghe, D. A.
Kliegel, M.
Ballhausen, N.
Gallacher, J.
Bauermeister, S.
Cumulative life course adversity, mental health, and cognition in the UK biobank
title Cumulative life course adversity, mental health, and cognition in the UK biobank
title_full Cumulative life course adversity, mental health, and cognition in the UK biobank
title_fullStr Cumulative life course adversity, mental health, and cognition in the UK biobank
title_full_unstemmed Cumulative life course adversity, mental health, and cognition in the UK biobank
title_short Cumulative life course adversity, mental health, and cognition in the UK biobank
title_sort cumulative life course adversity, mental health, and cognition in the uk biobank
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424182/
https://www.ncbi.nlm.nih.gov/pubmed/36038622
http://dx.doi.org/10.1038/s41598-022-18928-9
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