Cell death affecting the progression of gastric cancer

Gastric cancer is a gastrointestinal tumor with high morbidity and mortality rates. Several factors influence its progression, cell death being an important element. In this review, we summarized the effects of necrosis, apoptosis, necroptosis, pyroptosis, ferroptosis, and eight less common cell dea...

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Autores principales: Wang, Haoying, Liu, Mengxiao, Zeng, Xi, Zheng, Ya, Wang, Yuping, Zhou, Yongning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424204/
https://www.ncbi.nlm.nih.gov/pubmed/36038533
http://dx.doi.org/10.1038/s41420-022-01161-8
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author Wang, Haoying
Liu, Mengxiao
Zeng, Xi
Zheng, Ya
Wang, Yuping
Zhou, Yongning
author_facet Wang, Haoying
Liu, Mengxiao
Zeng, Xi
Zheng, Ya
Wang, Yuping
Zhou, Yongning
author_sort Wang, Haoying
collection PubMed
description Gastric cancer is a gastrointestinal tumor with high morbidity and mortality rates. Several factors influence its progression, cell death being an important element. In this review, we summarized the effects of necrosis, apoptosis, necroptosis, pyroptosis, ferroptosis, and eight less common cell death modalities on gastric cancer cells and the tumor microenvironment, detailed the molecular mechanisms of various cell death and their major regulatory pathways in gastric cancer, explored the prevalence and complexity of cell death in gastric cancer progression and highlighted the potentials of cell death-related therapies in gastric cancer.
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spelling pubmed-94242042022-08-31 Cell death affecting the progression of gastric cancer Wang, Haoying Liu, Mengxiao Zeng, Xi Zheng, Ya Wang, Yuping Zhou, Yongning Cell Death Discov Review Article Gastric cancer is a gastrointestinal tumor with high morbidity and mortality rates. Several factors influence its progression, cell death being an important element. In this review, we summarized the effects of necrosis, apoptosis, necroptosis, pyroptosis, ferroptosis, and eight less common cell death modalities on gastric cancer cells and the tumor microenvironment, detailed the molecular mechanisms of various cell death and their major regulatory pathways in gastric cancer, explored the prevalence and complexity of cell death in gastric cancer progression and highlighted the potentials of cell death-related therapies in gastric cancer. Nature Publishing Group UK 2022-08-29 /pmc/articles/PMC9424204/ /pubmed/36038533 http://dx.doi.org/10.1038/s41420-022-01161-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Wang, Haoying
Liu, Mengxiao
Zeng, Xi
Zheng, Ya
Wang, Yuping
Zhou, Yongning
Cell death affecting the progression of gastric cancer
title Cell death affecting the progression of gastric cancer
title_full Cell death affecting the progression of gastric cancer
title_fullStr Cell death affecting the progression of gastric cancer
title_full_unstemmed Cell death affecting the progression of gastric cancer
title_short Cell death affecting the progression of gastric cancer
title_sort cell death affecting the progression of gastric cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424204/
https://www.ncbi.nlm.nih.gov/pubmed/36038533
http://dx.doi.org/10.1038/s41420-022-01161-8
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