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Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function

8-Oxoguanine DNA glycosylase (OGG1) initiates base excision repair of the oxidative DNA damage product 8-oxoguanine. OGG1 is bifunctional; catalyzing glycosyl bond cleavage, followed by phosphodiester backbone incision via a β-elimination apurinic lyase reaction. The product from the glycosylase rea...

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Detalles Bibliográficos
Autores principales:	Tian, Gaochao, Katchur, Steven R., Jiang, Yong, Briand, Jacques, Schaber, Michael, Kreatsoulas, Constantine, Schwartz, Benjamin, Thrall, Sara, Davis, Alicia M., Duvall, Sam, Kaufman, Brett A., Rumsey, William L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424235/ https://www.ncbi.nlm.nih.gov/pubmed/36038587 http://dx.doi.org/10.1038/s41598-022-18878-2

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