Antipsychotics function as epigenetic age regulators in human neuroblastoma cells

Recent epigenetic age studies suggested accelerated aging in schizophrenia. Although antipsychotics may modulate epigenetic age, direct estimation of their roles was impeded when tissues derived from patients were used for analysis. By using a cellular model, we found that antipsychotics generally w...

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Detalles Bibliográficos
Autores principales: Du, Jianbin, Nakachi, Yutaka, Fujii, Ayaka, Fujii, Shinya, Bundo, Miki, Iwamoto, Kazuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424249/
https://www.ncbi.nlm.nih.gov/pubmed/36038613
http://dx.doi.org/10.1038/s41537-022-00277-1
Descripción
Sumario:Recent epigenetic age studies suggested accelerated aging in schizophrenia. Although antipsychotics may modulate epigenetic age, direct estimation of their roles was impeded when tissues derived from patients were used for analysis. By using a cellular model, we found that antipsychotics generally worked as epigenetic age regulators in vitro.

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