Antipsychotics function as epigenetic age regulators in human neuroblastoma cells

Recent epigenetic age studies suggested accelerated aging in schizophrenia. Although antipsychotics may modulate epigenetic age, direct estimation of their roles was impeded when tissues derived from patients were used for analysis. By using a cellular model, we found that antipsychotics generally w...

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Autores principales: Du, Jianbin, Nakachi, Yutaka, Fujii, Ayaka, Fujii, Shinya, Bundo, Miki, Iwamoto, Kazuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424249/
https://www.ncbi.nlm.nih.gov/pubmed/36038613
http://dx.doi.org/10.1038/s41537-022-00277-1
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author Du, Jianbin
Nakachi, Yutaka
Fujii, Ayaka
Fujii, Shinya
Bundo, Miki
Iwamoto, Kazuya
author_facet Du, Jianbin
Nakachi, Yutaka
Fujii, Ayaka
Fujii, Shinya
Bundo, Miki
Iwamoto, Kazuya
author_sort Du, Jianbin
collection PubMed
description Recent epigenetic age studies suggested accelerated aging in schizophrenia. Although antipsychotics may modulate epigenetic age, direct estimation of their roles was impeded when tissues derived from patients were used for analysis. By using a cellular model, we found that antipsychotics generally worked as epigenetic age regulators in vitro.
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spelling pubmed-94242492022-08-31 Antipsychotics function as epigenetic age regulators in human neuroblastoma cells Du, Jianbin Nakachi, Yutaka Fujii, Ayaka Fujii, Shinya Bundo, Miki Iwamoto, Kazuya Schizophrenia (Heidelb) Brief Communication Recent epigenetic age studies suggested accelerated aging in schizophrenia. Although antipsychotics may modulate epigenetic age, direct estimation of their roles was impeded when tissues derived from patients were used for analysis. By using a cellular model, we found that antipsychotics generally worked as epigenetic age regulators in vitro. Nature Publishing Group UK 2022-08-29 /pmc/articles/PMC9424249/ /pubmed/36038613 http://dx.doi.org/10.1038/s41537-022-00277-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Du, Jianbin
Nakachi, Yutaka
Fujii, Ayaka
Fujii, Shinya
Bundo, Miki
Iwamoto, Kazuya
Antipsychotics function as epigenetic age regulators in human neuroblastoma cells
title Antipsychotics function as epigenetic age regulators in human neuroblastoma cells
title_full Antipsychotics function as epigenetic age regulators in human neuroblastoma cells
title_fullStr Antipsychotics function as epigenetic age regulators in human neuroblastoma cells
title_full_unstemmed Antipsychotics function as epigenetic age regulators in human neuroblastoma cells
title_short Antipsychotics function as epigenetic age regulators in human neuroblastoma cells
title_sort antipsychotics function as epigenetic age regulators in human neuroblastoma cells
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424249/
https://www.ncbi.nlm.nih.gov/pubmed/36038613
http://dx.doi.org/10.1038/s41537-022-00277-1
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