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Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip

To correctly aminoacylate tRNA(Leu), leucyl-tRNA synthetase (LeuRS) catalyzes three reactions: activation of leucine by ATP to form leucyl-adenylate (Leu-AMP), transfer of this amino acid to tRNA(Leu) and post-transfer editing of any mischarged product. Although LeuRS has been well characterized bio...

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Detalles Bibliográficos
Autores principales:	Pang, Luping, Zanki, Vladimir, Strelkov, Sergei V., Van Aerschot, Arthur, Gruic-Sovulj, Ita, Weeks, Stephen D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424281/ https://www.ncbi.nlm.nih.gov/pubmed/36038645 http://dx.doi.org/10.1038/s42003-022-03825-8

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