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TLR agonists induce sustained IgG to hemagglutinin stem and modulate T cells following newborn vaccination

The newborn immune system is characterized by diminished immune responses that leave infants vulnerable to virus-mediated disease and make vaccination more challenging. Optimal vaccination strategies for influenza A virus (IAV) in newborns should result in robust levels of protective antibodies, inc...

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Detalles Bibliográficos
Autores principales: Clemens, Elene A., Holbrook, Beth C., McNeilly, Brendan, Kanekiyo, Masaru, Graham, Barney S., Alexander-Miller, Martha A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424286/
https://www.ncbi.nlm.nih.gov/pubmed/36038596
http://dx.doi.org/10.1038/s41541-022-00523-8

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