Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis

BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. The NLRP3 inflammasome, a platform for caspase-1 activation and release of interleukin 1β, is increasingly recognized in the induction of inflammation and liver fibrosis during NA...

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Detalles Bibliográficos
Autores principales: Kaufmann, Benedikt, Kui, Lin, Reca, Agustina, Leszczynska, Aleksandra, Kim, Andrea D., Booshehri, Laela M., Wree, Alexander, Friess, Helmut, Hartmann, Daniel, Broderick, Lori, Hoffman, Hal M., Feldstein, Ariel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424559/
https://www.ncbi.nlm.nih.gov/pubmed/35787975
http://dx.doi.org/10.1016/j.jcmgh.2022.06.007

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