Cargando…

Radial artery lumen diameter and intima thickness in patients with abdominal aortic aneurysm

OBJECTIVE: Abdominal aortic aneurysm (AAA) is associated with dilatation of central elastic arteries, while it is uncertain whether peripheral muscular arteries are affected. The aim of this study was to investigate radial artery diastolic lumen diameter (LD), wall thickness, and circumferential wal...

Descripción completa

Detalles Bibliográficos
Autores principales: Shlimon, Kristian, Lindenberger, Marcus, Welander, Martin, Dangardt, Frida, Bjarnegård, Niclas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424594/
https://www.ncbi.nlm.nih.gov/pubmed/36052216
http://dx.doi.org/10.1016/j.jvssci.2022.06.001
_version_ 1784778256566714368
author Shlimon, Kristian
Lindenberger, Marcus
Welander, Martin
Dangardt, Frida
Bjarnegård, Niclas
author_facet Shlimon, Kristian
Lindenberger, Marcus
Welander, Martin
Dangardt, Frida
Bjarnegård, Niclas
author_sort Shlimon, Kristian
collection PubMed
description OBJECTIVE: Abdominal aortic aneurysm (AAA) is associated with dilatation of central elastic arteries, while it is uncertain whether peripheral muscular arteries are affected. The aim of this study was to investigate radial artery diastolic lumen diameter (LD), wall thickness, and circumferential wall stress (CWS) in patients with AAA. METHODS: We included 130 men with AAA (mean age, 70.4 ± 3.5 years) and 61 men without AAA (mean age, 70.5 ± 3.2 years) in the study. High-frequency ultrasound examination (50 MHz) was used to measure radial artery diameter, wall thickness, and CWS was calculated. RESULTS: Men with AAA exhibited smaller radial artery LD (2.34 ± 0.42 mm vs 2.50 ± 0.38 mm; P < .01), thicker intima (0.094 ± 0.024 mm vs 0.081 ± 0.018 mm; P < .001), similar intima-media (0.28 ± 0.05 vs 0.26 ± 0.05 mm; P = NS), and lower CWS (42.9 ± 10.2 kPa vs 48.6 ± 11.4 kPa; P < .001), compared with controls. Subgroup analyses including all patients showed smaller LD and thicker intima in patients on statin therapy versus no statin therapy and current/ex-smoking versus never smoking. Individuals with hypertension versus no hypertension also presented with thicker intima, but with no difference in LD. CONCLUSIONS: AAAs demonstrated a smaller LD and thicker intima in the radial artery, in contrast with the theory of a general dilating diathesis of the arteries. Apart from AAA, other factors such as atherosclerosis, smoking habits, and hypertension might also be determinants of radial artery caliber and thickness. CLINICAL RELEVANCE: The clinical relevance of this study is the added insight into the pathophysiology of abdominal aortic aneurysm (AAA). Today, the management of AAA is focused on reduction of general cardiovascular risk factors and treatment is based on surgical approaches when the AAA is already manifest. By shedding light on unknown pathophysiological aspects of AAA, it will eventually be possible to develop targeted pharmacological treatments to prevent the formation of AAA, to halt disease progression, and to find early cardiovascular markers of AAA.
format Online
Article
Text
id pubmed-9424594
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-94245942022-08-31 Radial artery lumen diameter and intima thickness in patients with abdominal aortic aneurysm Shlimon, Kristian Lindenberger, Marcus Welander, Martin Dangardt, Frida Bjarnegård, Niclas JVS Vasc Sci Article OBJECTIVE: Abdominal aortic aneurysm (AAA) is associated with dilatation of central elastic arteries, while it is uncertain whether peripheral muscular arteries are affected. The aim of this study was to investigate radial artery diastolic lumen diameter (LD), wall thickness, and circumferential wall stress (CWS) in patients with AAA. METHODS: We included 130 men with AAA (mean age, 70.4 ± 3.5 years) and 61 men without AAA (mean age, 70.5 ± 3.2 years) in the study. High-frequency ultrasound examination (50 MHz) was used to measure radial artery diameter, wall thickness, and CWS was calculated. RESULTS: Men with AAA exhibited smaller radial artery LD (2.34 ± 0.42 mm vs 2.50 ± 0.38 mm; P < .01), thicker intima (0.094 ± 0.024 mm vs 0.081 ± 0.018 mm; P < .001), similar intima-media (0.28 ± 0.05 vs 0.26 ± 0.05 mm; P = NS), and lower CWS (42.9 ± 10.2 kPa vs 48.6 ± 11.4 kPa; P < .001), compared with controls. Subgroup analyses including all patients showed smaller LD and thicker intima in patients on statin therapy versus no statin therapy and current/ex-smoking versus never smoking. Individuals with hypertension versus no hypertension also presented with thicker intima, but with no difference in LD. CONCLUSIONS: AAAs demonstrated a smaller LD and thicker intima in the radial artery, in contrast with the theory of a general dilating diathesis of the arteries. Apart from AAA, other factors such as atherosclerosis, smoking habits, and hypertension might also be determinants of radial artery caliber and thickness. CLINICAL RELEVANCE: The clinical relevance of this study is the added insight into the pathophysiology of abdominal aortic aneurysm (AAA). Today, the management of AAA is focused on reduction of general cardiovascular risk factors and treatment is based on surgical approaches when the AAA is already manifest. By shedding light on unknown pathophysiological aspects of AAA, it will eventually be possible to develop targeted pharmacological treatments to prevent the formation of AAA, to halt disease progression, and to find early cardiovascular markers of AAA. Elsevier 2022-08-06 /pmc/articles/PMC9424594/ /pubmed/36052216 http://dx.doi.org/10.1016/j.jvssci.2022.06.001 Text en © 2022 by the Society for Vascular Surgery. Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shlimon, Kristian
Lindenberger, Marcus
Welander, Martin
Dangardt, Frida
Bjarnegård, Niclas
Radial artery lumen diameter and intima thickness in patients with abdominal aortic aneurysm
title Radial artery lumen diameter and intima thickness in patients with abdominal aortic aneurysm
title_full Radial artery lumen diameter and intima thickness in patients with abdominal aortic aneurysm
title_fullStr Radial artery lumen diameter and intima thickness in patients with abdominal aortic aneurysm
title_full_unstemmed Radial artery lumen diameter and intima thickness in patients with abdominal aortic aneurysm
title_short Radial artery lumen diameter and intima thickness in patients with abdominal aortic aneurysm
title_sort radial artery lumen diameter and intima thickness in patients with abdominal aortic aneurysm
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424594/
https://www.ncbi.nlm.nih.gov/pubmed/36052216
http://dx.doi.org/10.1016/j.jvssci.2022.06.001
work_keys_str_mv AT shlimonkristian radialarterylumendiameterandintimathicknessinpatientswithabdominalaorticaneurysm
AT lindenbergermarcus radialarterylumendiameterandintimathicknessinpatientswithabdominalaorticaneurysm
AT welandermartin radialarterylumendiameterandintimathicknessinpatientswithabdominalaorticaneurysm
AT dangardtfrida radialarterylumendiameterandintimathicknessinpatientswithabdominalaorticaneurysm
AT bjarnegardniclas radialarterylumendiameterandintimathicknessinpatientswithabdominalaorticaneurysm