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A comparative study of three bone age assessment methods on Chinese preschool-aged children

BACKGROUND: Bone age assessment (BAA) is an essential tool utilized in outpatient pediatric clinics. Three major BAA methods, Greulich–Pyle (GP), Tanner–Whitehouse 3 (TW3), and China 05 RUS–CHN (RUS–CHN), were applied to comprehensively compare bone age (BA) and chronological age (CA) in a Chinese s...

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Autores principales: Gao, Chengcheng, Qian, Qi, Li, Yangsheng, Xing, Xiaowei, He, Xiao, Lin, Min, Ding, Zhongxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424682/
https://www.ncbi.nlm.nih.gov/pubmed/36052363
http://dx.doi.org/10.3389/fped.2022.976565
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author Gao, Chengcheng
Qian, Qi
Li, Yangsheng
Xing, Xiaowei
He, Xiao
Lin, Min
Ding, Zhongxiang
author_facet Gao, Chengcheng
Qian, Qi
Li, Yangsheng
Xing, Xiaowei
He, Xiao
Lin, Min
Ding, Zhongxiang
author_sort Gao, Chengcheng
collection PubMed
description BACKGROUND: Bone age assessment (BAA) is an essential tool utilized in outpatient pediatric clinics. Three major BAA methods, Greulich–Pyle (GP), Tanner–Whitehouse 3 (TW3), and China 05 RUS–CHN (RUS–CHN), were applied to comprehensively compare bone age (BA) and chronological age (CA) in a Chinese sample of preschool children. This study was designed to determine the most reliable method. METHODS: The BAA sample consisted of 207 females and 183 males aged 3–6 years from the Zhejiang Province in China. The radiographs were estimated according to the GP, TW3, and RUS–CHN methods by two pediatric radiologists. The data was analyzed statistically using boxplots, the Wilcoxon rank test, and Student’s t-test to explore the difference (D) between BA and CA. RESULTS: According to the distributions of D, the boxplots showed that the median D of the TW3 method was close to zero for both male and female subjects. The TW3 and RUS–CHN methods overestimated the age of both genders. The TW3 method had the highest correct classification rate for males but a similar rate for females. The GP method did not show any significant difference between the BA and CA when applied to 3-year-old males and 4-year-old females while the TW3 method showed similar results when applied to 6-year-old females. The RUS–CHN method showed the least consistent results among the three methods. CONCLUSION: The TW3 method was superior to the GP and RUS–CHN methods but not reliable on its own. It should be noted that a precise age diagnosis for preschool children cannot be easily made if only one of the methods is utilized. Therefore, it is advantageous to combine multiple methods when assessing bone age.
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spelling pubmed-94246822022-08-31 A comparative study of three bone age assessment methods on Chinese preschool-aged children Gao, Chengcheng Qian, Qi Li, Yangsheng Xing, Xiaowei He, Xiao Lin, Min Ding, Zhongxiang Front Pediatr Pediatrics BACKGROUND: Bone age assessment (BAA) is an essential tool utilized in outpatient pediatric clinics. Three major BAA methods, Greulich–Pyle (GP), Tanner–Whitehouse 3 (TW3), and China 05 RUS–CHN (RUS–CHN), were applied to comprehensively compare bone age (BA) and chronological age (CA) in a Chinese sample of preschool children. This study was designed to determine the most reliable method. METHODS: The BAA sample consisted of 207 females and 183 males aged 3–6 years from the Zhejiang Province in China. The radiographs were estimated according to the GP, TW3, and RUS–CHN methods by two pediatric radiologists. The data was analyzed statistically using boxplots, the Wilcoxon rank test, and Student’s t-test to explore the difference (D) between BA and CA. RESULTS: According to the distributions of D, the boxplots showed that the median D of the TW3 method was close to zero for both male and female subjects. The TW3 and RUS–CHN methods overestimated the age of both genders. The TW3 method had the highest correct classification rate for males but a similar rate for females. The GP method did not show any significant difference between the BA and CA when applied to 3-year-old males and 4-year-old females while the TW3 method showed similar results when applied to 6-year-old females. The RUS–CHN method showed the least consistent results among the three methods. CONCLUSION: The TW3 method was superior to the GP and RUS–CHN methods but not reliable on its own. It should be noted that a precise age diagnosis for preschool children cannot be easily made if only one of the methods is utilized. Therefore, it is advantageous to combine multiple methods when assessing bone age. Frontiers Media S.A. 2022-08-16 /pmc/articles/PMC9424682/ /pubmed/36052363 http://dx.doi.org/10.3389/fped.2022.976565 Text en Copyright © 2022 Gao, Qian, Li, Xing, He, Lin and Ding. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Gao, Chengcheng
Qian, Qi
Li, Yangsheng
Xing, Xiaowei
He, Xiao
Lin, Min
Ding, Zhongxiang
A comparative study of three bone age assessment methods on Chinese preschool-aged children
title A comparative study of three bone age assessment methods on Chinese preschool-aged children
title_full A comparative study of three bone age assessment methods on Chinese preschool-aged children
title_fullStr A comparative study of three bone age assessment methods on Chinese preschool-aged children
title_full_unstemmed A comparative study of three bone age assessment methods on Chinese preschool-aged children
title_short A comparative study of three bone age assessment methods on Chinese preschool-aged children
title_sort comparative study of three bone age assessment methods on chinese preschool-aged children
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424682/
https://www.ncbi.nlm.nih.gov/pubmed/36052363
http://dx.doi.org/10.3389/fped.2022.976565
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