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Effects of the PLK4 inhibitor Centrinone on the biological behaviors of acute myeloid leukemia cell lines

Polo-like kinase 4 (PLK4), a key regulator of centriole biogenesis, is frequently overexpressed in cancer cells. However, roles and the mechanism of PLK4 in the leukemiagenesis of acute myeloid leukemia (AML) remain unclear. In this study, the PLK4 inhibitor Centrinone and the shRNA knockdown were u...

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Detalles Bibliográficos
Autores principales:	Mu, Xing-Ru, Ma, Meng-Meng, Lu, Zi-Yi, Liu, Jun, Xue, Yu-Tong, Cao, Jiang, Zeng, Ling-Yu, Li, Feng, Xu, Kai-Lin, Wu, Qing-Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424683/ https://www.ncbi.nlm.nih.gov/pubmed/36051696 http://dx.doi.org/10.3389/fgene.2022.898474

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