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Z1456467176 alleviates gouty arthritis by allosterically modulating P2X7R to inhibit NLRP3 inflammasome activation

NLRP3 inflammasome activation is a central process in initiating gout flares. The unique conformational rearrangement of the P2X7 receptor (P2X7R) upon ATP binding is critical for the activation of the NLRP3 inflammasome. However, studies on allosteric modulation of P2X7R in gout treatment are limit...

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Detalles Bibliográficos
Autores principales:	Li, Xiaoling, Liu, Yiming, Luo, Chengyu, Tao, Jinhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424684/ https://www.ncbi.nlm.nih.gov/pubmed/36052144 http://dx.doi.org/10.3389/fphar.2022.979939

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