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Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1

Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs stalled type I topoisomerase (TOP1)-DNA complexes by hydrolyzing the phosphodiester bond between the TOP1 Y723 residue and the 3′-phosphate of its DNA substrate. Although TDP1 antagonists could potentially reduce the dose of TOP1 inhibitors needed to ac...

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Detalles Bibliográficos
Autores principales:	Zhao, Xue Zhi, Wang, Wenjie, Lountos, George T., Tropea, Joseph E., Needle, Danielle, Pommier, Yves, Burke, Terrence R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424690/ https://www.ncbi.nlm.nih.gov/pubmed/36051621 http://dx.doi.org/10.3389/fchem.2022.910953

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