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Health Effects Associated With Humidifier Disinfectant Use: A Systematic Review for Exploration
BACKGROUND: It has been 10 years since the outbreak of lung disease caused by humidifier disinfectants in Korea, but the health effects have not yet been summarized. Therefore, this study aims to systematically examine the health effects of humidifier disinfectants that have been discovered so far....
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424740/ https://www.ncbi.nlm.nih.gov/pubmed/35996934 http://dx.doi.org/10.3346/jkms.2022.37.e257 |
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author | Song, Ji-Hun Ahn, Joonho Park, Min Young Park, Jaeyoung Lee, Yu Min Myong, Jun-Pyo Koo, Jung-Wan Lee, Jongin |
author_facet | Song, Ji-Hun Ahn, Joonho Park, Min Young Park, Jaeyoung Lee, Yu Min Myong, Jun-Pyo Koo, Jung-Wan Lee, Jongin |
author_sort | Song, Ji-Hun |
collection | PubMed |
description | BACKGROUND: It has been 10 years since the outbreak of lung disease caused by humidifier disinfectants in Korea, but the health effects have not yet been summarized. Therefore, this study aims to systematically examine the health effects of humidifier disinfectants that have been discovered so far. METHODS: All literature with humidifier disinfectants and their representative components as the main words were collected based on the web, including PubMed, Research Information Sharing Service, and government publication reports. A total of 902 studies were searched, of which 196 were selected. They were divided into four groups: published human studies (group 1), published animal and cytotoxicology studies (group 2), technical reports (group 3), and gray literature (group 4). RESULTS: Out of the 196 studies, 97 (49.5%) were published in peer-reviewed journals as original research. Group 1 consisted of 49 articles (50.5%), while group 2 consisted of 48 articles (49.5%). Overall, respiratory diseases such as humidifier disinfectant associated lung injury, interstitial lung disease, and asthma have a clear correlation, but other effects such as liver, heart, thymus, thyroid, fetal growth, metabolic abnormalities, and eyes are observed in toxicological experimental studies, but have not yet been identified in epidemiologic studies. CONCLUSION: The current level of evidence does not completely rule out the effects of humidifier disinfectants on extrapulmonary disease. Based on the toxicological evidence so far, it is required to monitor the population of humidifier disinfectant exposure continuously to see if similar damage occurs. |
format | Online Article Text |
id | pubmed-9424740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-94247402022-09-06 Health Effects Associated With Humidifier Disinfectant Use: A Systematic Review for Exploration Song, Ji-Hun Ahn, Joonho Park, Min Young Park, Jaeyoung Lee, Yu Min Myong, Jun-Pyo Koo, Jung-Wan Lee, Jongin J Korean Med Sci Review Article BACKGROUND: It has been 10 years since the outbreak of lung disease caused by humidifier disinfectants in Korea, but the health effects have not yet been summarized. Therefore, this study aims to systematically examine the health effects of humidifier disinfectants that have been discovered so far. METHODS: All literature with humidifier disinfectants and their representative components as the main words were collected based on the web, including PubMed, Research Information Sharing Service, and government publication reports. A total of 902 studies were searched, of which 196 were selected. They were divided into four groups: published human studies (group 1), published animal and cytotoxicology studies (group 2), technical reports (group 3), and gray literature (group 4). RESULTS: Out of the 196 studies, 97 (49.5%) were published in peer-reviewed journals as original research. Group 1 consisted of 49 articles (50.5%), while group 2 consisted of 48 articles (49.5%). Overall, respiratory diseases such as humidifier disinfectant associated lung injury, interstitial lung disease, and asthma have a clear correlation, but other effects such as liver, heart, thymus, thyroid, fetal growth, metabolic abnormalities, and eyes are observed in toxicological experimental studies, but have not yet been identified in epidemiologic studies. CONCLUSION: The current level of evidence does not completely rule out the effects of humidifier disinfectants on extrapulmonary disease. Based on the toxicological evidence so far, it is required to monitor the population of humidifier disinfectant exposure continuously to see if similar damage occurs. The Korean Academy of Medical Sciences 2022-08-12 /pmc/articles/PMC9424740/ /pubmed/35996934 http://dx.doi.org/10.3346/jkms.2022.37.e257 Text en © 2022 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Song, Ji-Hun Ahn, Joonho Park, Min Young Park, Jaeyoung Lee, Yu Min Myong, Jun-Pyo Koo, Jung-Wan Lee, Jongin Health Effects Associated With Humidifier Disinfectant Use: A Systematic Review for Exploration |
title | Health Effects Associated With Humidifier Disinfectant Use: A Systematic Review for Exploration |
title_full | Health Effects Associated With Humidifier Disinfectant Use: A Systematic Review for Exploration |
title_fullStr | Health Effects Associated With Humidifier Disinfectant Use: A Systematic Review for Exploration |
title_full_unstemmed | Health Effects Associated With Humidifier Disinfectant Use: A Systematic Review for Exploration |
title_short | Health Effects Associated With Humidifier Disinfectant Use: A Systematic Review for Exploration |
title_sort | health effects associated with humidifier disinfectant use: a systematic review for exploration |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424740/ https://www.ncbi.nlm.nih.gov/pubmed/35996934 http://dx.doi.org/10.3346/jkms.2022.37.e257 |
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