Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors

Morphine, the most widely used analgesic, relieves severe pain by activating the μ-opioid receptor (MOR), whereas naloxone, with only slight structural changes compared to morphine, exhibits inhibitory effect, and is used to treat opioid abuse. The mechanism by which the MOR distinguishes between th...

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Detalles Bibliográficos
Autores principales: Zhang, Xin, Sun, Meng-Yang, Zhang, Xue, Guo, Chang-Run, Lei, Yun-Tao, Wang, Wen-Hui, Fan, Ying-Zhe, Cao, Peng, Li, Chang-Zhu, Wang, Rui, Li, Xing-Hua, Yu, Ye, Yang, Xiao-Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424762/
https://www.ncbi.nlm.nih.gov/pubmed/36052166
http://dx.doi.org/10.3389/fmolb.2022.925404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424762/
https://www.ncbi.nlm.nih.gov/pubmed/36052166
http://dx.doi.org/10.3389/fmolb.2022.925404

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