Intersections of endocrine pathways and the epithelial mesenchymal transition in endometrial cancer

The epithelial mesenchymal transition (EMT) is the process by which cancer cells of epithelial origin, including endometrial cancer, acquire a mesenchymal phenotype with enhanced migratory and invasive capacity, to facilitate metastasis. The regulation of EMT is tissue-specific, and in endometrial c...

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Detalles Bibliográficos
Autores principales: Gelissen, Julia H., Huang, Gloria S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424890/
https://www.ncbi.nlm.nih.gov/pubmed/36052252
http://dx.doi.org/10.3389/fonc.2022.914405
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author Gelissen, Julia H.
Huang, Gloria S.
author_facet Gelissen, Julia H.
Huang, Gloria S.
author_sort Gelissen, Julia H.
collection PubMed
description The epithelial mesenchymal transition (EMT) is the process by which cancer cells of epithelial origin, including endometrial cancer, acquire a mesenchymal phenotype with enhanced migratory and invasive capacity, to facilitate metastasis. The regulation of EMT is tissue-specific, and in endometrial cancer, endocrine signaling pathways serve as critical regulators of EMT. The intersections of endocrine signaling and EMT highlight potential avenues for therapeutic intervention to target cancer metastasis with the aim of reduced mortality.
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spelling pubmed-94248902022-08-31 Intersections of endocrine pathways and the epithelial mesenchymal transition in endometrial cancer Gelissen, Julia H. Huang, Gloria S. Front Oncol Oncology The epithelial mesenchymal transition (EMT) is the process by which cancer cells of epithelial origin, including endometrial cancer, acquire a mesenchymal phenotype with enhanced migratory and invasive capacity, to facilitate metastasis. The regulation of EMT is tissue-specific, and in endometrial cancer, endocrine signaling pathways serve as critical regulators of EMT. The intersections of endocrine signaling and EMT highlight potential avenues for therapeutic intervention to target cancer metastasis with the aim of reduced mortality. Frontiers Media S.A. 2022-08-16 /pmc/articles/PMC9424890/ /pubmed/36052252 http://dx.doi.org/10.3389/fonc.2022.914405 Text en Copyright © 2022 Gelissen and Huang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Gelissen, Julia H.
Huang, Gloria S.
Intersections of endocrine pathways and the epithelial mesenchymal transition in endometrial cancer
title Intersections of endocrine pathways and the epithelial mesenchymal transition in endometrial cancer
title_full Intersections of endocrine pathways and the epithelial mesenchymal transition in endometrial cancer
title_fullStr Intersections of endocrine pathways and the epithelial mesenchymal transition in endometrial cancer
title_full_unstemmed Intersections of endocrine pathways and the epithelial mesenchymal transition in endometrial cancer
title_short Intersections of endocrine pathways and the epithelial mesenchymal transition in endometrial cancer
title_sort intersections of endocrine pathways and the epithelial mesenchymal transition in endometrial cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424890/
https://www.ncbi.nlm.nih.gov/pubmed/36052252
http://dx.doi.org/10.3389/fonc.2022.914405
work_keys_str_mv AT gelissenjuliah intersectionsofendocrinepathwaysandtheepithelialmesenchymaltransitioninendometrialcancer
AT huangglorias intersectionsofendocrinepathwaysandtheepithelialmesenchymaltransitioninendometrialcancer

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