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The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer

Colorectal cancer (CRC) is one of the most significant neoplasms with high morbidity and mortality. Activation of the programmed death protein 1/programmed death ligand 1 (PD-1/PD-L1) signaling pathway results in tumor immune evasion by suppressing the activity of T cells. The correlation of soluble...

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Autores principales: Shao, Weifang, Xu, Yanhua, Lin, Suzhen, Gao, Junli, Gao, Junshun, Wang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424923/
https://www.ncbi.nlm.nih.gov/pubmed/36052227
http://dx.doi.org/10.3389/fonc.2022.988567
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author Shao, Weifang
Xu, Yanhua
Lin, Suzhen
Gao, Junli
Gao, Junshun
Wang, Hong
author_facet Shao, Weifang
Xu, Yanhua
Lin, Suzhen
Gao, Junli
Gao, Junshun
Wang, Hong
author_sort Shao, Weifang
collection PubMed
description Colorectal cancer (CRC) is one of the most significant neoplasms with high morbidity and mortality. Activation of the programmed death protein 1/programmed death ligand 1 (PD-1/PD-L1) signaling pathway results in tumor immune evasion by suppressing the activity of T cells. The correlation of soluble PD-L1 (sPD-L1) in serum/plasma with clinicopathological features, lymph node metastasis, diagnosis and prognosis is less clear. The aim of this study was to investigate the relationship between sPD-L1 and clinicopathological features, and diagnosis potentialof CRC. Three hundred patients with CRC were included in this study. sPD-L1 was measured by ELISA. Pretreatment levels of sPD-L1 were significantly elevated in CRC patient sera compared to healthy control (HC) (P<0.001). The median value of sPD-L1 in HC, CRC with non-lymph node metastasis, and CRC with lymph node metastasis were 246.78±50.2pg/mL, 284.12±52.7pg/mL, and 321.31±55.3pg/mL, respectively. ROC analysis of sPD-L1 allowed significant differentiation between HC group and CRC group (lymph node metastasis and non lymph node metastasis (AUC=0.861, 95% CI 0.830-0.887, p<0.001). sPD-L1 is a potential biomarker for the diagnosis of CRC. Multivariate analysis showed that lymph node metastasis and tumor differentiation were independent prognostic factors (all P< 0.01), and sPD-L1 was not correlated with the CRC prognosis (p>0.05).
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spelling pubmed-94249232022-08-31 The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer Shao, Weifang Xu, Yanhua Lin, Suzhen Gao, Junli Gao, Junshun Wang, Hong Front Oncol Oncology Colorectal cancer (CRC) is one of the most significant neoplasms with high morbidity and mortality. Activation of the programmed death protein 1/programmed death ligand 1 (PD-1/PD-L1) signaling pathway results in tumor immune evasion by suppressing the activity of T cells. The correlation of soluble PD-L1 (sPD-L1) in serum/plasma with clinicopathological features, lymph node metastasis, diagnosis and prognosis is less clear. The aim of this study was to investigate the relationship between sPD-L1 and clinicopathological features, and diagnosis potentialof CRC. Three hundred patients with CRC were included in this study. sPD-L1 was measured by ELISA. Pretreatment levels of sPD-L1 were significantly elevated in CRC patient sera compared to healthy control (HC) (P<0.001). The median value of sPD-L1 in HC, CRC with non-lymph node metastasis, and CRC with lymph node metastasis were 246.78±50.2pg/mL, 284.12±52.7pg/mL, and 321.31±55.3pg/mL, respectively. ROC analysis of sPD-L1 allowed significant differentiation between HC group and CRC group (lymph node metastasis and non lymph node metastasis (AUC=0.861, 95% CI 0.830-0.887, p<0.001). sPD-L1 is a potential biomarker for the diagnosis of CRC. Multivariate analysis showed that lymph node metastasis and tumor differentiation were independent prognostic factors (all P< 0.01), and sPD-L1 was not correlated with the CRC prognosis (p>0.05). Frontiers Media S.A. 2022-08-16 /pmc/articles/PMC9424923/ /pubmed/36052227 http://dx.doi.org/10.3389/fonc.2022.988567 Text en Copyright © 2022 Shao, Xu, Lin, Gao, Gao and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Shao, Weifang
Xu, Yanhua
Lin, Suzhen
Gao, Junli
Gao, Junshun
Wang, Hong
The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer
title The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer
title_full The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer
title_fullStr The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer
title_full_unstemmed The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer
title_short The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer
title_sort potential of soluble programmed death-ligand 1 (spd-l1) as a diagnosis marker for colorectal cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424923/
https://www.ncbi.nlm.nih.gov/pubmed/36052227
http://dx.doi.org/10.3389/fonc.2022.988567
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