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The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer
Colorectal cancer (CRC) is one of the most significant neoplasms with high morbidity and mortality. Activation of the programmed death protein 1/programmed death ligand 1 (PD-1/PD-L1) signaling pathway results in tumor immune evasion by suppressing the activity of T cells. The correlation of soluble...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424923/ https://www.ncbi.nlm.nih.gov/pubmed/36052227 http://dx.doi.org/10.3389/fonc.2022.988567 |
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author | Shao, Weifang Xu, Yanhua Lin, Suzhen Gao, Junli Gao, Junshun Wang, Hong |
author_facet | Shao, Weifang Xu, Yanhua Lin, Suzhen Gao, Junli Gao, Junshun Wang, Hong |
author_sort | Shao, Weifang |
collection | PubMed |
description | Colorectal cancer (CRC) is one of the most significant neoplasms with high morbidity and mortality. Activation of the programmed death protein 1/programmed death ligand 1 (PD-1/PD-L1) signaling pathway results in tumor immune evasion by suppressing the activity of T cells. The correlation of soluble PD-L1 (sPD-L1) in serum/plasma with clinicopathological features, lymph node metastasis, diagnosis and prognosis is less clear. The aim of this study was to investigate the relationship between sPD-L1 and clinicopathological features, and diagnosis potentialof CRC. Three hundred patients with CRC were included in this study. sPD-L1 was measured by ELISA. Pretreatment levels of sPD-L1 were significantly elevated in CRC patient sera compared to healthy control (HC) (P<0.001). The median value of sPD-L1 in HC, CRC with non-lymph node metastasis, and CRC with lymph node metastasis were 246.78±50.2pg/mL, 284.12±52.7pg/mL, and 321.31±55.3pg/mL, respectively. ROC analysis of sPD-L1 allowed significant differentiation between HC group and CRC group (lymph node metastasis and non lymph node metastasis (AUC=0.861, 95% CI 0.830-0.887, p<0.001). sPD-L1 is a potential biomarker for the diagnosis of CRC. Multivariate analysis showed that lymph node metastasis and tumor differentiation were independent prognostic factors (all P< 0.01), and sPD-L1 was not correlated with the CRC prognosis (p>0.05). |
format | Online Article Text |
id | pubmed-9424923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94249232022-08-31 The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer Shao, Weifang Xu, Yanhua Lin, Suzhen Gao, Junli Gao, Junshun Wang, Hong Front Oncol Oncology Colorectal cancer (CRC) is one of the most significant neoplasms with high morbidity and mortality. Activation of the programmed death protein 1/programmed death ligand 1 (PD-1/PD-L1) signaling pathway results in tumor immune evasion by suppressing the activity of T cells. The correlation of soluble PD-L1 (sPD-L1) in serum/plasma with clinicopathological features, lymph node metastasis, diagnosis and prognosis is less clear. The aim of this study was to investigate the relationship between sPD-L1 and clinicopathological features, and diagnosis potentialof CRC. Three hundred patients with CRC were included in this study. sPD-L1 was measured by ELISA. Pretreatment levels of sPD-L1 were significantly elevated in CRC patient sera compared to healthy control (HC) (P<0.001). The median value of sPD-L1 in HC, CRC with non-lymph node metastasis, and CRC with lymph node metastasis were 246.78±50.2pg/mL, 284.12±52.7pg/mL, and 321.31±55.3pg/mL, respectively. ROC analysis of sPD-L1 allowed significant differentiation between HC group and CRC group (lymph node metastasis and non lymph node metastasis (AUC=0.861, 95% CI 0.830-0.887, p<0.001). sPD-L1 is a potential biomarker for the diagnosis of CRC. Multivariate analysis showed that lymph node metastasis and tumor differentiation were independent prognostic factors (all P< 0.01), and sPD-L1 was not correlated with the CRC prognosis (p>0.05). Frontiers Media S.A. 2022-08-16 /pmc/articles/PMC9424923/ /pubmed/36052227 http://dx.doi.org/10.3389/fonc.2022.988567 Text en Copyright © 2022 Shao, Xu, Lin, Gao, Gao and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Shao, Weifang Xu, Yanhua Lin, Suzhen Gao, Junli Gao, Junshun Wang, Hong The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer |
title | The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer |
title_full | The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer |
title_fullStr | The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer |
title_full_unstemmed | The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer |
title_short | The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer |
title_sort | potential of soluble programmed death-ligand 1 (spd-l1) as a diagnosis marker for colorectal cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424923/ https://www.ncbi.nlm.nih.gov/pubmed/36052227 http://dx.doi.org/10.3389/fonc.2022.988567 |
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