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Therapeutic Hyper-CL soft contact lens in Sjögren's syndrome
PURPOSE: To report increased corneal bioavailability of allogenic serum when used in combinations with Therapeutic Hyper-CL™ soft contact lens in a patient with severe Sjögren's syndrome-associated dry eye. OBSERVATIONS: A 57-year-old woman with a medical history of bilateral severe Sjögren...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424940/ https://www.ncbi.nlm.nih.gov/pubmed/36051188 http://dx.doi.org/10.1016/j.ajoc.2022.101685 |
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author | Romano, Vito Romano, Davide Semeraro, Paolo Forbice, Eliana Iaria, Antonio Pizzolante, Teodoro Frassi, Micol Franceschini, Franco Semeraro, Francesco |
author_facet | Romano, Vito Romano, Davide Semeraro, Paolo Forbice, Eliana Iaria, Antonio Pizzolante, Teodoro Frassi, Micol Franceschini, Franco Semeraro, Francesco |
author_sort | Romano, Vito |
collection | PubMed |
description | PURPOSE: To report increased corneal bioavailability of allogenic serum when used in combinations with Therapeutic Hyper-CL™ soft contact lens in a patient with severe Sjögren's syndrome-associated dry eye. OBSERVATIONS: A 57-year-old woman with a medical history of bilateral severe Sjögren's syndrome-associated dry eye and previous amniotic membrane patch for autoimmune corneal perforation in her left eye was referred for left eye recurrence of progressive melting and pending perforation. After manual corneal trephination, full thickness transplant and sutured amniotic membrane patch, a Therapeutic Hyper-CL™ soft contact lens (EyeYon Medical, Ness Tziona, Israel) was fit. The patient was commenced in the left eye with topical corticosteroid, antibiotic, and allogenic serum eye drops. In the right eye the patient had silicone hydrogel bandage contact lens and was under same treatment of the left eye for previous endothelial keratoplasty. In order to evaluate the efficacy and increased corneal availability of drugs provided by Therapeutic Hyper-CL™ compared with silicone hydrogel soft contact lens, anterior segment OCT was performed. CONCLUSIONS AND IMPORTANCE: The anterior segment OCT showed a thicker meniscus of fluid and possibly subsequent increase of trophic factors bioavailability in left eye compared with right eye. Therefore, in case of severe and refractory dry-eye disease the combination of Therapeutic Hyper-CL™ and serum eye drops may be representing a valid therapeutic approach. |
format | Online Article Text |
id | pubmed-9424940 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94249402022-08-31 Therapeutic Hyper-CL soft contact lens in Sjögren's syndrome Romano, Vito Romano, Davide Semeraro, Paolo Forbice, Eliana Iaria, Antonio Pizzolante, Teodoro Frassi, Micol Franceschini, Franco Semeraro, Francesco Am J Ophthalmol Case Rep Case Report PURPOSE: To report increased corneal bioavailability of allogenic serum when used in combinations with Therapeutic Hyper-CL™ soft contact lens in a patient with severe Sjögren's syndrome-associated dry eye. OBSERVATIONS: A 57-year-old woman with a medical history of bilateral severe Sjögren's syndrome-associated dry eye and previous amniotic membrane patch for autoimmune corneal perforation in her left eye was referred for left eye recurrence of progressive melting and pending perforation. After manual corneal trephination, full thickness transplant and sutured amniotic membrane patch, a Therapeutic Hyper-CL™ soft contact lens (EyeYon Medical, Ness Tziona, Israel) was fit. The patient was commenced in the left eye with topical corticosteroid, antibiotic, and allogenic serum eye drops. In the right eye the patient had silicone hydrogel bandage contact lens and was under same treatment of the left eye for previous endothelial keratoplasty. In order to evaluate the efficacy and increased corneal availability of drugs provided by Therapeutic Hyper-CL™ compared with silicone hydrogel soft contact lens, anterior segment OCT was performed. CONCLUSIONS AND IMPORTANCE: The anterior segment OCT showed a thicker meniscus of fluid and possibly subsequent increase of trophic factors bioavailability in left eye compared with right eye. Therefore, in case of severe and refractory dry-eye disease the combination of Therapeutic Hyper-CL™ and serum eye drops may be representing a valid therapeutic approach. Elsevier 2022-08-19 /pmc/articles/PMC9424940/ /pubmed/36051188 http://dx.doi.org/10.1016/j.ajoc.2022.101685 Text en © 2022 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Romano, Vito Romano, Davide Semeraro, Paolo Forbice, Eliana Iaria, Antonio Pizzolante, Teodoro Frassi, Micol Franceschini, Franco Semeraro, Francesco Therapeutic Hyper-CL soft contact lens in Sjögren's syndrome |
title | Therapeutic Hyper-CL soft contact lens in Sjögren's syndrome |
title_full | Therapeutic Hyper-CL soft contact lens in Sjögren's syndrome |
title_fullStr | Therapeutic Hyper-CL soft contact lens in Sjögren's syndrome |
title_full_unstemmed | Therapeutic Hyper-CL soft contact lens in Sjögren's syndrome |
title_short | Therapeutic Hyper-CL soft contact lens in Sjögren's syndrome |
title_sort | therapeutic hyper-cl soft contact lens in sjögren's syndrome |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424940/ https://www.ncbi.nlm.nih.gov/pubmed/36051188 http://dx.doi.org/10.1016/j.ajoc.2022.101685 |
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