Single mutations toggle the substrate selectivity of multifunctional Camptotheca secologanic acid synthases

Terpene indole alkaloids (TIAs) are plant-derived specialized metabolites with widespread use in medicine. Species-specific pathways derive various TIAs from common intermediates, strictosidine or strictosidinic acid, produced by coupling tryptamine with secologanin or secologanic acid. The penultim...

Descripción completa

Detalles Bibliográficos
Autores principales: Miller, Justin C., Schuler, Mary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424959/
https://www.ncbi.nlm.nih.gov/pubmed/35809640
http://dx.doi.org/10.1016/j.jbc.2022.102237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424959/
https://www.ncbi.nlm.nih.gov/pubmed/35809640
http://dx.doi.org/10.1016/j.jbc.2022.102237

Ejemplares similares