Cargando…
Bile acids in immunity: Bidirectional mediators between the host and the microbiota
Host-microbiota interactions are bidirectional. On one hand, ecological pressures exerted by the host shape the composition and function of the microbiota. On the other, resident microbes trigger multiple pathways that influence the immunity of the host. Bile acids participate in both parts of this...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425027/ https://www.ncbi.nlm.nih.gov/pubmed/36052074 http://dx.doi.org/10.3389/fimmu.2022.949033 |
_version_ | 1784778356946894848 |
---|---|
author | Godlewska, Urszula Bulanda, Edyta Wypych, Tomasz P. |
author_facet | Godlewska, Urszula Bulanda, Edyta Wypych, Tomasz P. |
author_sort | Godlewska, Urszula |
collection | PubMed |
description | Host-microbiota interactions are bidirectional. On one hand, ecological pressures exerted by the host shape the composition and function of the microbiota. On the other, resident microbes trigger multiple pathways that influence the immunity of the host. Bile acids participate in both parts of this interplay. As host-derived compounds, they display bacteriostatic properties and affect the survival and growth of the members of the microbial community. As microbiota-modified metabolites, they further influence the microbiota composition and, in parallel, modulate the immunity of the host. Here, we provide a comprehensive overview of the mechanisms behind this unique dialogue and discuss how we can harness bile acids to treat intestinal inflammation. |
format | Online Article Text |
id | pubmed-9425027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94250272022-08-31 Bile acids in immunity: Bidirectional mediators between the host and the microbiota Godlewska, Urszula Bulanda, Edyta Wypych, Tomasz P. Front Immunol Immunology Host-microbiota interactions are bidirectional. On one hand, ecological pressures exerted by the host shape the composition and function of the microbiota. On the other, resident microbes trigger multiple pathways that influence the immunity of the host. Bile acids participate in both parts of this interplay. As host-derived compounds, they display bacteriostatic properties and affect the survival and growth of the members of the microbial community. As microbiota-modified metabolites, they further influence the microbiota composition and, in parallel, modulate the immunity of the host. Here, we provide a comprehensive overview of the mechanisms behind this unique dialogue and discuss how we can harness bile acids to treat intestinal inflammation. Frontiers Media S.A. 2022-08-16 /pmc/articles/PMC9425027/ /pubmed/36052074 http://dx.doi.org/10.3389/fimmu.2022.949033 Text en Copyright © 2022 Godlewska, Bulanda and Wypych https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Godlewska, Urszula Bulanda, Edyta Wypych, Tomasz P. Bile acids in immunity: Bidirectional mediators between the host and the microbiota |
title | Bile acids in immunity: Bidirectional mediators between the host and the microbiota |
title_full | Bile acids in immunity: Bidirectional mediators between the host and the microbiota |
title_fullStr | Bile acids in immunity: Bidirectional mediators between the host and the microbiota |
title_full_unstemmed | Bile acids in immunity: Bidirectional mediators between the host and the microbiota |
title_short | Bile acids in immunity: Bidirectional mediators between the host and the microbiota |
title_sort | bile acids in immunity: bidirectional mediators between the host and the microbiota |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425027/ https://www.ncbi.nlm.nih.gov/pubmed/36052074 http://dx.doi.org/10.3389/fimmu.2022.949033 |
work_keys_str_mv | AT godlewskaurszula bileacidsinimmunitybidirectionalmediatorsbetweenthehostandthemicrobiota AT bulandaedyta bileacidsinimmunitybidirectionalmediatorsbetweenthehostandthemicrobiota AT wypychtomaszp bileacidsinimmunitybidirectionalmediatorsbetweenthehostandthemicrobiota |