Intestinal Osteopontin Protects From Alcohol-induced Liver Injury by Preserving the Gut Microbiome and the Intestinal Barrier Function

BACKGROUND & AIMS: The gut-liver axis plays a key role in the pathogenesis of alcohol-associated liver disease (ALD). We demonstrated that Opn(-/-) develop worse ALD than wild-type (WT) mice; however, the role of intestinal osteopontin (OPN) in ALD remains unknown. We hypothesized that overexpre...

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Detalles Bibliográficos
Autores principales: Das, Sukanta, Song, Zhuolun, Han, Hui, Ge, Xiaodong, Desert, Romain, Athavale, Dipti, Babu Komakula, Sai Santosh, Magdaleno, Fernando, Chen, Wei, Lantvit, Daniel, Guzman, Grace, Nieto, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425038/
https://www.ncbi.nlm.nih.gov/pubmed/35811073
http://dx.doi.org/10.1016/j.jcmgh.2022.06.012

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