Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model

BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) is characterized by biliary senescence and hepatic fibrosis. Melatonin exerts its effects by interacting with Melatonin receptor 1 and 2 (MT1/MT2) melatonin receptors. Short-term (1 wk) melatonin treatment reduces a ductular reaction and li...

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Detalles Bibliográficos
Autores principales: Ceci, Ludovica, Chen, Lixian, Baiocchi, Leonardo, Wu, Nan, Kennedy, Lindsey, Carpino, Guido, Kyritsi, Konstantina, Zhou, Tianhao, Owen, Travis, Kundu, Debjyoti, Sybenga, Amelia, Isidan, Abdulkadir, Ekser, Burcin, Franchitto, Antonio, Onori, Paolo, Gaudio, Eugenio, Mancinelli, Romina, Francis, Heather, Alpini, Gianfranco, Glaser, Shannon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425041/
https://www.ncbi.nlm.nih.gov/pubmed/35863741
http://dx.doi.org/10.1016/j.jcmgh.2022.07.007

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