Nivolumab plus ipilimumab induced endocrinopathy and acute interstitial nephritis in metastatic sarcomatoid renal-cell carcinoma: A case report and review of literature

The prognosis of sarcomatoid renal cell carcinoma has changed dramatically with the emergence of immune checkpoint inhibitors. Notably the use of nivolumab and ipilimumab combination therapy has demonstrated promising durable therapeutic response for patients with treatment-naïve sarcomatoid renal-c...

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Autores principales: Hino, Christopher, Nishino, Kevin, Pham, Bryan, Jeon, Won Jin, Nguyen, Michael, Cao, Huynh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425087/
https://www.ncbi.nlm.nih.gov/pubmed/36052087
http://dx.doi.org/10.3389/fimmu.2022.993622
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author Hino, Christopher
Nishino, Kevin
Pham, Bryan
Jeon, Won Jin
Nguyen, Michael
Cao, Huynh
author_facet Hino, Christopher
Nishino, Kevin
Pham, Bryan
Jeon, Won Jin
Nguyen, Michael
Cao, Huynh
author_sort Hino, Christopher
collection PubMed
description The prognosis of sarcomatoid renal cell carcinoma has changed dramatically with the emergence of immune checkpoint inhibitors. Notably the use of nivolumab and ipilimumab combination therapy has demonstrated promising durable therapeutic response for patients with treatment-naïve sarcomatoid renal-cell carcinoma. We present a case of 45-year-old man with a history of metastatic sarcomatoid renal cell carcinoma treated with nivolumab plus ipilimumab who developed type 1 diabetes mellitus, adrenal insufficiency, thyroiditis/hypothyroidism, and acute interstitial nephritis as a result of immunotherapy.
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spelling pubmed-94250872022-08-31 Nivolumab plus ipilimumab induced endocrinopathy and acute interstitial nephritis in metastatic sarcomatoid renal-cell carcinoma: A case report and review of literature Hino, Christopher Nishino, Kevin Pham, Bryan Jeon, Won Jin Nguyen, Michael Cao, Huynh Front Immunol Immunology The prognosis of sarcomatoid renal cell carcinoma has changed dramatically with the emergence of immune checkpoint inhibitors. Notably the use of nivolumab and ipilimumab combination therapy has demonstrated promising durable therapeutic response for patients with treatment-naïve sarcomatoid renal-cell carcinoma. We present a case of 45-year-old man with a history of metastatic sarcomatoid renal cell carcinoma treated with nivolumab plus ipilimumab who developed type 1 diabetes mellitus, adrenal insufficiency, thyroiditis/hypothyroidism, and acute interstitial nephritis as a result of immunotherapy. Frontiers Media S.A. 2022-08-16 /pmc/articles/PMC9425087/ /pubmed/36052087 http://dx.doi.org/10.3389/fimmu.2022.993622 Text en Copyright © 2022 Hino, Nishino, Pham, Jeon, Nguyen and Cao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Hino, Christopher
Nishino, Kevin
Pham, Bryan
Jeon, Won Jin
Nguyen, Michael
Cao, Huynh
Nivolumab plus ipilimumab induced endocrinopathy and acute interstitial nephritis in metastatic sarcomatoid renal-cell carcinoma: A case report and review of literature
title Nivolumab plus ipilimumab induced endocrinopathy and acute interstitial nephritis in metastatic sarcomatoid renal-cell carcinoma: A case report and review of literature
title_full Nivolumab plus ipilimumab induced endocrinopathy and acute interstitial nephritis in metastatic sarcomatoid renal-cell carcinoma: A case report and review of literature
title_fullStr Nivolumab plus ipilimumab induced endocrinopathy and acute interstitial nephritis in metastatic sarcomatoid renal-cell carcinoma: A case report and review of literature
title_full_unstemmed Nivolumab plus ipilimumab induced endocrinopathy and acute interstitial nephritis in metastatic sarcomatoid renal-cell carcinoma: A case report and review of literature
title_short Nivolumab plus ipilimumab induced endocrinopathy and acute interstitial nephritis in metastatic sarcomatoid renal-cell carcinoma: A case report and review of literature
title_sort nivolumab plus ipilimumab induced endocrinopathy and acute interstitial nephritis in metastatic sarcomatoid renal-cell carcinoma: a case report and review of literature
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425087/
https://www.ncbi.nlm.nih.gov/pubmed/36052087
http://dx.doi.org/10.3389/fimmu.2022.993622
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