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Immune restoration in human immunodeficiency virus and hepatitis C virus coinfected patients after highly active antiretroviral therapy

OBJECTIVE: To evaluate the influence of hepatitis C virus on immunological and virological responses after highly active antiretroviral therapy initiation in human immunodeficiency virus/hepatitis C virus coinfected patients compared to monoinfected human immunodeficiency virus-infected patients. ME...

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Autores principales: Antonello, Vicente Sperb, Appel-da-Silva, Marcelo Campos, Kliemann, Dimas Alexandre, Santos, Breno Riegel, Tovo, Cristiane Valle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425133/
https://www.ncbi.nlm.nih.gov/pubmed/23831277
http://dx.doi.org/10.1016/j.bjid.2013.01.015
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author Antonello, Vicente Sperb
Appel-da-Silva, Marcelo Campos
Kliemann, Dimas Alexandre
Santos, Breno Riegel
Tovo, Cristiane Valle
author_facet Antonello, Vicente Sperb
Appel-da-Silva, Marcelo Campos
Kliemann, Dimas Alexandre
Santos, Breno Riegel
Tovo, Cristiane Valle
author_sort Antonello, Vicente Sperb
collection PubMed
description OBJECTIVE: To evaluate the influence of hepatitis C virus on immunological and virological responses after highly active antiretroviral therapy initiation in human immunodeficiency virus/hepatitis C virus coinfected patients compared to monoinfected human immunodeficiency virus-infected patients. METHODS: The study enrolled 65 human immunodeficiency virus-1-infected subjects who initiated highly active antiretroviral therapy and attended follow-up visits over 48 weeks from 2008 to 2010. They were grouped based on hepatitis C virus-RNA results. Virological and immunological responses were monitored at baseline and at the end of weeks 12, 24, 36, and 48. RESULTS: There were 35 human immunodeficiency virus monoinfected and 30 human immunodeficiency virus/hepatitis C virus coinfected patients. In the present study human immunodeficiency virus/hepatitis C virus coinfection did not seem to influence CD4 T-lymphocytes recovery. There was no difference between the curves of CD4 T-lymphocytes raise of coinfected and monoinfected groups. CONCLUSION: This prospective study confirms that hepatitis C virus infection does not seem to be associated with impaired CD4 T-lymphocytes recovery after HAART.
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spelling pubmed-94251332022-08-31 Immune restoration in human immunodeficiency virus and hepatitis C virus coinfected patients after highly active antiretroviral therapy Antonello, Vicente Sperb Appel-da-Silva, Marcelo Campos Kliemann, Dimas Alexandre Santos, Breno Riegel Tovo, Cristiane Valle Braz J Infect Dis Original Article OBJECTIVE: To evaluate the influence of hepatitis C virus on immunological and virological responses after highly active antiretroviral therapy initiation in human immunodeficiency virus/hepatitis C virus coinfected patients compared to monoinfected human immunodeficiency virus-infected patients. METHODS: The study enrolled 65 human immunodeficiency virus-1-infected subjects who initiated highly active antiretroviral therapy and attended follow-up visits over 48 weeks from 2008 to 2010. They were grouped based on hepatitis C virus-RNA results. Virological and immunological responses were monitored at baseline and at the end of weeks 12, 24, 36, and 48. RESULTS: There were 35 human immunodeficiency virus monoinfected and 30 human immunodeficiency virus/hepatitis C virus coinfected patients. In the present study human immunodeficiency virus/hepatitis C virus coinfection did not seem to influence CD4 T-lymphocytes recovery. There was no difference between the curves of CD4 T-lymphocytes raise of coinfected and monoinfected groups. CONCLUSION: This prospective study confirms that hepatitis C virus infection does not seem to be associated with impaired CD4 T-lymphocytes recovery after HAART. Elsevier 2013-07-04 /pmc/articles/PMC9425133/ /pubmed/23831277 http://dx.doi.org/10.1016/j.bjid.2013.01.015 Text en © 2013 Elsevier Editora Ltda. Este é um artigo Open Access sob a licença de CC BY-NC-ND. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Antonello, Vicente Sperb
Appel-da-Silva, Marcelo Campos
Kliemann, Dimas Alexandre
Santos, Breno Riegel
Tovo, Cristiane Valle
Immune restoration in human immunodeficiency virus and hepatitis C virus coinfected patients after highly active antiretroviral therapy
title Immune restoration in human immunodeficiency virus and hepatitis C virus coinfected patients after highly active antiretroviral therapy
title_full Immune restoration in human immunodeficiency virus and hepatitis C virus coinfected patients after highly active antiretroviral therapy
title_fullStr Immune restoration in human immunodeficiency virus and hepatitis C virus coinfected patients after highly active antiretroviral therapy
title_full_unstemmed Immune restoration in human immunodeficiency virus and hepatitis C virus coinfected patients after highly active antiretroviral therapy
title_short Immune restoration in human immunodeficiency virus and hepatitis C virus coinfected patients after highly active antiretroviral therapy
title_sort immune restoration in human immunodeficiency virus and hepatitis c virus coinfected patients after highly active antiretroviral therapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425133/
https://www.ncbi.nlm.nih.gov/pubmed/23831277
http://dx.doi.org/10.1016/j.bjid.2013.01.015
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