Immune responses to Leptospira infection: roles as biomarkers for disease severity

Various leptospiral components have been identified and shown to be involved in tissue destruction. In addition, immune responses to leptospires have been implicated in target organ damages in severe leptospirosis cases. Several inflammatory mediators were shown to be higher in susceptible animals t...

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Detalles Bibliográficos
Autores principales: Chirathaworn, Chintana, Kongpan, Sutthikarn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425245/
https://www.ncbi.nlm.nih.gov/pubmed/24275371
http://dx.doi.org/10.1016/j.bjid.2013.08.002
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author Chirathaworn, Chintana
Kongpan, Sutthikarn
author_facet Chirathaworn, Chintana
Kongpan, Sutthikarn
author_sort Chirathaworn, Chintana
collection PubMed
description Various leptospiral components have been identified and shown to be involved in tissue destruction. In addition, immune responses to leptospires have been implicated in target organ damages in severe leptospirosis cases. Several inflammatory mediators were shown to be higher in susceptible animals than in resistant hosts. Moreover, cytokines/chemokines and serum proteins induced following Leptospira infection were suggested to be biomarkers for disease severity in human leptospirosis. This review focuses on the role of immune responses in the severity of leptospirosis. Studies in both animal models and humans are discussed.
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spelling pubmed-94252452022-08-31 Immune responses to Leptospira infection: roles as biomarkers for disease severity Chirathaworn, Chintana Kongpan, Sutthikarn Braz J Infect Dis Review Article Various leptospiral components have been identified and shown to be involved in tissue destruction. In addition, immune responses to leptospires have been implicated in target organ damages in severe leptospirosis cases. Several inflammatory mediators were shown to be higher in susceptible animals than in resistant hosts. Moreover, cytokines/chemokines and serum proteins induced following Leptospira infection were suggested to be biomarkers for disease severity in human leptospirosis. This review focuses on the role of immune responses in the severity of leptospirosis. Studies in both animal models and humans are discussed. Elsevier 2013-11-22 /pmc/articles/PMC9425245/ /pubmed/24275371 http://dx.doi.org/10.1016/j.bjid.2013.08.002 Text en © 2013 Elsevier Editora Ltda. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Chirathaworn, Chintana
Kongpan, Sutthikarn
Immune responses to Leptospira infection: roles as biomarkers for disease severity
title Immune responses to Leptospira infection: roles as biomarkers for disease severity
title_full Immune responses to Leptospira infection: roles as biomarkers for disease severity
title_fullStr Immune responses to Leptospira infection: roles as biomarkers for disease severity
title_full_unstemmed Immune responses to Leptospira infection: roles as biomarkers for disease severity
title_short Immune responses to Leptospira infection: roles as biomarkers for disease severity
title_sort immune responses to leptospira infection: roles as biomarkers for disease severity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425245/
https://www.ncbi.nlm.nih.gov/pubmed/24275371
http://dx.doi.org/10.1016/j.bjid.2013.08.002
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