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Increased visceral fat distribution and body composition impact cytokine release syndrome onset and severity after CD19 chimeric antigen receptor T-cell therapy in advanced B-cell malignancies
Chimeric antigen receptor T-cell (CAR-T) therapy is associated with a distinct toxicity profile that includes cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). CRS is characterized by the release of pro-inflammatory cytokines such as interleukin 6 (I...
Autores principales: | Cordas dos Santos, David M., Rejeski, Kai, Winkelmann, Michael, Liu, Lian, Trinkner, Paul, Günther, Sophie, Bücklein, Veit L., Blumenberg, Viktoria, Schmidt, Christian, Kunz, Wolfgang G., von Bergwelt-Baildon, Michael, Theurich, Sebastian, Subklewe, Marion |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Fondazione Ferrata Storti
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425325/ https://www.ncbi.nlm.nih.gov/pubmed/35172565 http://dx.doi.org/10.3324/haematol.2021.280189 |
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