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Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease
Increased serum CA 19-9 levels in patients with nonmalignant diseases have been investigated in previous reports. This study evaluates the clinical significance of serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial disease and pulmonary tuberculosis. The median CA 19-9 level was highe...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425399/ https://www.ncbi.nlm.nih.gov/pubmed/26613892 http://dx.doi.org/10.1016/j.bjid.2015.09.005 |
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author | Hong, Ji Young Jang, Sun Hee Kim, Song Yee Chung, Kyung Soo Song, Joo Han Park, Moo Suk Kim, Young Sam Kim, Se Kyu Chang, Joon Kang, Young Ae |
author_facet | Hong, Ji Young Jang, Sun Hee Kim, Song Yee Chung, Kyung Soo Song, Joo Han Park, Moo Suk Kim, Young Sam Kim, Se Kyu Chang, Joon Kang, Young Ae |
author_sort | Hong, Ji Young |
collection | PubMed |
description | Increased serum CA 19-9 levels in patients with nonmalignant diseases have been investigated in previous reports. This study evaluates the clinical significance of serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial disease and pulmonary tuberculosis. The median CA 19-9 level was higher in patients with pulmonary nontuberculous mycobacterial disease than in patients with pulmonary tuberculosis (pulmonary nontuberculous mycobacterial disease: 13.80, tuberculosis: 5.85, p < 0.001). A multivariate logistic regression analysis performed in this study showed that Mycobacterium abscessus (OR 9.97, 95% CI: 1.58, 62.80; p = 0.014) and active phase of pulmonary nontuberculous mycobacterial disease (OR 12.18, 95% CI: 1.07, 138.36, p = 0.044) were found to be risk factors for serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial disease. The serum CA 19-9 levels showed a tendency to decrease during successful treatment of pulmonary nontuberculous mycobacterial disease but not in pulmonary tuberculosis. These findings suggest that CA 19-9 may be a useful marker for monitoring therapeutic responses in pulmonary nontuberculous mycobacterial disease, although it is not pulmonary nontuberculous mycobacterial disease-specific marker. |
format | Online Article Text |
id | pubmed-9425399 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94253992022-08-31 Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease Hong, Ji Young Jang, Sun Hee Kim, Song Yee Chung, Kyung Soo Song, Joo Han Park, Moo Suk Kim, Young Sam Kim, Se Kyu Chang, Joon Kang, Young Ae Braz J Infect Dis Original Article Increased serum CA 19-9 levels in patients with nonmalignant diseases have been investigated in previous reports. This study evaluates the clinical significance of serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial disease and pulmonary tuberculosis. The median CA 19-9 level was higher in patients with pulmonary nontuberculous mycobacterial disease than in patients with pulmonary tuberculosis (pulmonary nontuberculous mycobacterial disease: 13.80, tuberculosis: 5.85, p < 0.001). A multivariate logistic regression analysis performed in this study showed that Mycobacterium abscessus (OR 9.97, 95% CI: 1.58, 62.80; p = 0.014) and active phase of pulmonary nontuberculous mycobacterial disease (OR 12.18, 95% CI: 1.07, 138.36, p = 0.044) were found to be risk factors for serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial disease. The serum CA 19-9 levels showed a tendency to decrease during successful treatment of pulmonary nontuberculous mycobacterial disease but not in pulmonary tuberculosis. These findings suggest that CA 19-9 may be a useful marker for monitoring therapeutic responses in pulmonary nontuberculous mycobacterial disease, although it is not pulmonary nontuberculous mycobacterial disease-specific marker. Elsevier 2015-11-22 /pmc/articles/PMC9425399/ /pubmed/26613892 http://dx.doi.org/10.1016/j.bjid.2015.09.005 Text en © 2015 Elsevier Editora Ltda. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Hong, Ji Young Jang, Sun Hee Kim, Song Yee Chung, Kyung Soo Song, Joo Han Park, Moo Suk Kim, Young Sam Kim, Se Kyu Chang, Joon Kang, Young Ae Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease |
title | Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease |
title_full | Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease |
title_fullStr | Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease |
title_full_unstemmed | Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease |
title_short | Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease |
title_sort | elevated serum ca 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425399/ https://www.ncbi.nlm.nih.gov/pubmed/26613892 http://dx.doi.org/10.1016/j.bjid.2015.09.005 |
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