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Roles of cysteine in the structure and metabolic function of Mycobacterium tuberculosis CYP142A1

CYP142A1 is a cytochrome P450 (CYP) enzyme expressed in Mycobacterium tuberculosis (Mtb), which supports the growth of Mtb H37Rv relying on cholesterol, in the absence of CYP125A1. Since cysteine residues usually play a fundamental role in maintaining the structure and function of CYP enzymes, in th...

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Detalles Bibliográficos
Autores principales: Lu, Yun, Sun, Lilan, Pang, Jing, Li, Congran, Wang, Xiukun, Hu, Xinxin, Li, Guoqing, Li, Xue, Zhang, Youwen, Wang, Hao, Yang, Xinyi, You, Xuefu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425443/
https://www.ncbi.nlm.nih.gov/pubmed/36128375
http://dx.doi.org/10.1039/d2ra04257f