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Increasing rates of Clostridium difficile infection in Mexican hospitals

INTRODUCTION: The epidemiology of Clostridium difficile infection (CDI) has changed in the last two decades. There is a lack of information regarding incidence and severity of CDI, especially in the developing world. METHODS: This was a retrospective and observational study from four hospitals of th...

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Autores principales: Dávila, Laura Palau, Garza-González, Elvira, Rodríguez-Zulueta, Patricia, Morfín-Otero, Rayo, Rodríguez-Noriega, Eduardo, Vilar-Compte, Diana, Rodríguez-Aldama, Juan C., Camacho-Ortiz, Adrián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425492/
https://www.ncbi.nlm.nih.gov/pubmed/28641091
http://dx.doi.org/10.1016/j.bjid.2017.05.007
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author Dávila, Laura Palau
Garza-González, Elvira
Rodríguez-Zulueta, Patricia
Morfín-Otero, Rayo
Rodríguez-Noriega, Eduardo
Vilar-Compte, Diana
Rodríguez-Aldama, Juan C.
Camacho-Ortiz, Adrián
author_facet Dávila, Laura Palau
Garza-González, Elvira
Rodríguez-Zulueta, Patricia
Morfín-Otero, Rayo
Rodríguez-Noriega, Eduardo
Vilar-Compte, Diana
Rodríguez-Aldama, Juan C.
Camacho-Ortiz, Adrián
author_sort Dávila, Laura Palau
collection PubMed
description INTRODUCTION: The epidemiology of Clostridium difficile infection (CDI) has changed in the last two decades. There is a lack of information regarding incidence and severity of CDI, especially in the developing world. METHODS: This was a retrospective and observational study from four hospitals of three Mexican cities. Patients were diagnosed with CDI when presented with loose stools and had at least one of the following tests positive: toxins assay, real-time PCR, or an endoscopic image compatible with pseudomembranous colitis. CDI was classified according to international guidelines. Demographic and clinical data as well as information regarding total hospital admissions, total length-of-hospital stay, and other variables related to hospitalization were gathered from the epidemiology and administration departments of each hospital. RESULTS: A total of 2050 hospital beds were analyzed with 288,171 patients hospitalized accumulating 1,576,446 days of hospitalization during the study period. The average rate of CDI per 1000 hospital-days was lower than the rates reported in the US and Europe, although in 2015 CDI rates were almost persistently above the mean rate for the study period. More than half of PCR positive patients were ribotype 027. CONCLUSION: Hospital rates of CDI are increasing in Mexican hospitals with a predominance of infections caused by ribotype 027.
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spelling pubmed-94254922022-08-31 Increasing rates of Clostridium difficile infection in Mexican hospitals Dávila, Laura Palau Garza-González, Elvira Rodríguez-Zulueta, Patricia Morfín-Otero, Rayo Rodríguez-Noriega, Eduardo Vilar-Compte, Diana Rodríguez-Aldama, Juan C. Camacho-Ortiz, Adrián Braz J Infect Dis Original Article INTRODUCTION: The epidemiology of Clostridium difficile infection (CDI) has changed in the last two decades. There is a lack of information regarding incidence and severity of CDI, especially in the developing world. METHODS: This was a retrospective and observational study from four hospitals of three Mexican cities. Patients were diagnosed with CDI when presented with loose stools and had at least one of the following tests positive: toxins assay, real-time PCR, or an endoscopic image compatible with pseudomembranous colitis. CDI was classified according to international guidelines. Demographic and clinical data as well as information regarding total hospital admissions, total length-of-hospital stay, and other variables related to hospitalization were gathered from the epidemiology and administration departments of each hospital. RESULTS: A total of 2050 hospital beds were analyzed with 288,171 patients hospitalized accumulating 1,576,446 days of hospitalization during the study period. The average rate of CDI per 1000 hospital-days was lower than the rates reported in the US and Europe, although in 2015 CDI rates were almost persistently above the mean rate for the study period. More than half of PCR positive patients were ribotype 027. CONCLUSION: Hospital rates of CDI are increasing in Mexican hospitals with a predominance of infections caused by ribotype 027. Elsevier 2017-06-20 /pmc/articles/PMC9425492/ /pubmed/28641091 http://dx.doi.org/10.1016/j.bjid.2017.05.007 Text en © 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Dávila, Laura Palau
Garza-González, Elvira
Rodríguez-Zulueta, Patricia
Morfín-Otero, Rayo
Rodríguez-Noriega, Eduardo
Vilar-Compte, Diana
Rodríguez-Aldama, Juan C.
Camacho-Ortiz, Adrián
Increasing rates of Clostridium difficile infection in Mexican hospitals
title Increasing rates of Clostridium difficile infection in Mexican hospitals
title_full Increasing rates of Clostridium difficile infection in Mexican hospitals
title_fullStr Increasing rates of Clostridium difficile infection in Mexican hospitals
title_full_unstemmed Increasing rates of Clostridium difficile infection in Mexican hospitals
title_short Increasing rates of Clostridium difficile infection in Mexican hospitals
title_sort increasing rates of clostridium difficile infection in mexican hospitals
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425492/
https://www.ncbi.nlm.nih.gov/pubmed/28641091
http://dx.doi.org/10.1016/j.bjid.2017.05.007
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