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In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid

INTRODUCTION: Treatment of multidrug-resistant Gram-positive infections caused by Staphylococcus aureus remains as a clinical challenge due to emergence of new resistance mechanisms. Tedizolid is a next-generation oxazolidinone, recently approved for skin and soft tissues infections. We conducted a...

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Autores principales: Vanegas Múnera, Johanna Marcela, Ocampo Ríos, Ana María, Urrego, Daniela Montoya, Jiménez Quiceno, Judy Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425527/
https://www.ncbi.nlm.nih.gov/pubmed/28432878
http://dx.doi.org/10.1016/j.bjid.2017.03.010
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author Vanegas Múnera, Johanna Marcela
Ocampo Ríos, Ana María
Urrego, Daniela Montoya
Jiménez Quiceno, Judy Natalia
author_facet Vanegas Múnera, Johanna Marcela
Ocampo Ríos, Ana María
Urrego, Daniela Montoya
Jiménez Quiceno, Judy Natalia
author_sort Vanegas Múnera, Johanna Marcela
collection PubMed
description INTRODUCTION: Treatment of multidrug-resistant Gram-positive infections caused by Staphylococcus aureus remains as a clinical challenge due to emergence of new resistance mechanisms. Tedizolid is a next-generation oxazolidinone, recently approved for skin and soft tissues infections. We conducted a study to determine in vitro susceptibility to vancomycin, daptomycin, linezolid and tedizolid in MRSA clinical isolates from adult patients with skin and soft tissue infections. MATERIAL AND METHODS: Methicillin-resistant S. aureus isolates were collected in three tertiary-care hospitals of Medellin, Colombia, from February 2008 to June 2010 as part of a previous study. Clinical characteristics were assessed by medical records and MIC values were determined by Epsilometer test. Genotypic analysis included spa typing, MLST, and SCCmec typing. RESULTS: A total of 150 MRSA isolates were evaluated and tedizolid MIC values obtained showed higher in vitro activity than other antimicrobials, with MIC values ranging from 0.13 μg/mL to 0.75 μg/mL and lower values of MIC(50) and MIC(90) (0.38 μg/mL and 0.5 μg/mL)(.) In contrast, vancomycin and linezolid had higher MIC values, which ranged from 0.5 μg/mL to 2.0 μg/mL and from 0.38 μg/mL to 4.0 μg/mL, respectively. Tedizolid MICs were 2- to 5-fold lower than those of linezolid. Clinical characteristics showed high previous antimicrobial use and hospitalization history. The majority of the strains belong to the CC8 harboring the SCCmec IVc and were associated with the spa t1610 (29.33%, n = 44). CONCLUSION: In vitro effectiveness of tedizolid was superior for isolates from skin and soft tissue infections in comparison with the other antibiotics evaluated. The above added to its less toxicity, good bioavailability, daily dose and unnecessity of dosage adjustment, make tedizolid in a promising alternative for the treatment of infections caused by MRSA.
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spelling pubmed-94255272022-08-31 In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid Vanegas Múnera, Johanna Marcela Ocampo Ríos, Ana María Urrego, Daniela Montoya Jiménez Quiceno, Judy Natalia Braz J Infect Dis Original Article INTRODUCTION: Treatment of multidrug-resistant Gram-positive infections caused by Staphylococcus aureus remains as a clinical challenge due to emergence of new resistance mechanisms. Tedizolid is a next-generation oxazolidinone, recently approved for skin and soft tissues infections. We conducted a study to determine in vitro susceptibility to vancomycin, daptomycin, linezolid and tedizolid in MRSA clinical isolates from adult patients with skin and soft tissue infections. MATERIAL AND METHODS: Methicillin-resistant S. aureus isolates were collected in three tertiary-care hospitals of Medellin, Colombia, from February 2008 to June 2010 as part of a previous study. Clinical characteristics were assessed by medical records and MIC values were determined by Epsilometer test. Genotypic analysis included spa typing, MLST, and SCCmec typing. RESULTS: A total of 150 MRSA isolates were evaluated and tedizolid MIC values obtained showed higher in vitro activity than other antimicrobials, with MIC values ranging from 0.13 μg/mL to 0.75 μg/mL and lower values of MIC(50) and MIC(90) (0.38 μg/mL and 0.5 μg/mL)(.) In contrast, vancomycin and linezolid had higher MIC values, which ranged from 0.5 μg/mL to 2.0 μg/mL and from 0.38 μg/mL to 4.0 μg/mL, respectively. Tedizolid MICs were 2- to 5-fold lower than those of linezolid. Clinical characteristics showed high previous antimicrobial use and hospitalization history. The majority of the strains belong to the CC8 harboring the SCCmec IVc and were associated with the spa t1610 (29.33%, n = 44). CONCLUSION: In vitro effectiveness of tedizolid was superior for isolates from skin and soft tissue infections in comparison with the other antibiotics evaluated. The above added to its less toxicity, good bioavailability, daily dose and unnecessity of dosage adjustment, make tedizolid in a promising alternative for the treatment of infections caused by MRSA. Elsevier 2017-04-19 /pmc/articles/PMC9425527/ /pubmed/28432878 http://dx.doi.org/10.1016/j.bjid.2017.03.010 Text en © 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Vanegas Múnera, Johanna Marcela
Ocampo Ríos, Ana María
Urrego, Daniela Montoya
Jiménez Quiceno, Judy Natalia
In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid
title In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid
title_full In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid
title_fullStr In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid
title_full_unstemmed In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid
title_short In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid
title_sort in vitro susceptibility of methicillin-resistant staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425527/
https://www.ncbi.nlm.nih.gov/pubmed/28432878
http://dx.doi.org/10.1016/j.bjid.2017.03.010
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