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Role of Mast Cells in the Pathogenesis of Pruritus in Mastocytosis

Pruritus can be defined as an unpleasant sensation that evokes a desire to scratch and significantly impairs patients’ quality of life. Pruritus is widely observed in many dermatoses, including mastocytosis, a rare disease characterized by abnormal accumulation of mast cells, which can involve skin,...

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Autores principales: KWIATKOWSKA, Dominika, REICH, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Publication of Acta Dermato-Venereologica 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425624/
https://www.ncbi.nlm.nih.gov/pubmed/34642766
http://dx.doi.org/10.2340/actadv.v101.350
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author KWIATKOWSKA, Dominika
REICH, Adam
author_facet KWIATKOWSKA, Dominika
REICH, Adam
author_sort KWIATKOWSKA, Dominika
collection PubMed
description Pruritus can be defined as an unpleasant sensation that evokes a desire to scratch and significantly impairs patients’ quality of life. Pruritus is widely observed in many dermatoses, including mastocytosis, a rare disease characterized by abnormal accumulation of mast cells, which can involve skin, bone marrow, and other organs. Increasing evidence highlights the role of mast cells in neurogenic inflammation and itching. Mast cells release various pruritogenic mediators, initiating subsequent mutual communication with specific nociceptors on sensory nerve fibres. Among important mediators released by mast cells that induce pruritus, one can distinguish histamine, serotonin, proteases, as well as various cytokines. During neuronal-induced inflammation, mast cells may respond to numerous mediators, including neuropeptides, such as substance P, neurokinin A, calcitonin gene-related peptide, endothelin 1, and nerve growth factor. Currently, treatment of pruritus in mastocytosis is focused on alleviating the effects of mediators secreted by mast cells. However, a deeper understanding of the intricacies of the neurobiology of this disease could help to provide better treatment options for patients.
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spelling pubmed-94256242022-10-20 Role of Mast Cells in the Pathogenesis of Pruritus in Mastocytosis KWIATKOWSKA, Dominika REICH, Adam Acta Derm Venereol Review Article Pruritus can be defined as an unpleasant sensation that evokes a desire to scratch and significantly impairs patients’ quality of life. Pruritus is widely observed in many dermatoses, including mastocytosis, a rare disease characterized by abnormal accumulation of mast cells, which can involve skin, bone marrow, and other organs. Increasing evidence highlights the role of mast cells in neurogenic inflammation and itching. Mast cells release various pruritogenic mediators, initiating subsequent mutual communication with specific nociceptors on sensory nerve fibres. Among important mediators released by mast cells that induce pruritus, one can distinguish histamine, serotonin, proteases, as well as various cytokines. During neuronal-induced inflammation, mast cells may respond to numerous mediators, including neuropeptides, such as substance P, neurokinin A, calcitonin gene-related peptide, endothelin 1, and nerve growth factor. Currently, treatment of pruritus in mastocytosis is focused on alleviating the effects of mediators secreted by mast cells. However, a deeper understanding of the intricacies of the neurobiology of this disease could help to provide better treatment options for patients. Society for Publication of Acta Dermato-Venereologica 2021-10-31 /pmc/articles/PMC9425624/ /pubmed/34642766 http://dx.doi.org/10.2340/actadv.v101.350 Text en © 2021 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license
spellingShingle Review Article
KWIATKOWSKA, Dominika
REICH, Adam
Role of Mast Cells in the Pathogenesis of Pruritus in Mastocytosis
title Role of Mast Cells in the Pathogenesis of Pruritus in Mastocytosis
title_full Role of Mast Cells in the Pathogenesis of Pruritus in Mastocytosis
title_fullStr Role of Mast Cells in the Pathogenesis of Pruritus in Mastocytosis
title_full_unstemmed Role of Mast Cells in the Pathogenesis of Pruritus in Mastocytosis
title_short Role of Mast Cells in the Pathogenesis of Pruritus in Mastocytosis
title_sort role of mast cells in the pathogenesis of pruritus in mastocytosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425624/
https://www.ncbi.nlm.nih.gov/pubmed/34642766
http://dx.doi.org/10.2340/actadv.v101.350
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