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Chronic skull osteomyelitis due to Cryptococcus neoformans: first case report in an HIV-infected patient
Osteomyelitis due to Cryptococcus neoformans are described in mostly 10% of patients with disseminated cryptococcosis, being direct inoculation even more uncommon. We report the case of an HIV-infected patient with history of recurring itching on his scalp and repetitive local trauma. For eighteen m...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425647/ https://www.ncbi.nlm.nih.gov/pubmed/30528189 http://dx.doi.org/10.1016/j.bjid.2018.11.004 |
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author | Adiwardana, Natanael Sutikno Morás, Juliana de Angelo Bernardo, Leandro Lombo Klautau, Giselle Burlamaqui Queiroz, Wladimir Vidal, Jose Ernesto |
author_facet | Adiwardana, Natanael Sutikno Morás, Juliana de Angelo Bernardo, Leandro Lombo Klautau, Giselle Burlamaqui Queiroz, Wladimir Vidal, Jose Ernesto |
author_sort | Adiwardana, Natanael Sutikno |
collection | PubMed |
description | Osteomyelitis due to Cryptococcus neoformans are described in mostly 10% of patients with disseminated cryptococcosis, being direct inoculation even more uncommon. We report the case of an HIV-infected patient with history of recurring itching on his scalp and repetitive local trauma. For eighteen months, he noticed a painful and slow growing lump on his scalp. He was submitted to an excisional biopsy of the lesion but no etiological diagnosis was identified. After this procedure, the post-surgical wound never completely healed. At admission, the patient presented nausea and headache for three days and an open orifice into his skull. Investigations confirmed meningitis and skull osteomyelitis caused by Cryptococcus neoformans. He was treated with bone debridement and combined systemic antifungals, showing good clinical and laboratorial outcome. Cryptococcal disease should be included in the differential diagnoses of chronic osteomyelitis in HIV-infected patients and trauma is a possible source of infection. |
format | Online Article Text |
id | pubmed-9425647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94256472022-08-31 Chronic skull osteomyelitis due to Cryptococcus neoformans: first case report in an HIV-infected patient Adiwardana, Natanael Sutikno Morás, Juliana de Angelo Bernardo, Leandro Lombo Klautau, Giselle Burlamaqui Queiroz, Wladimir Vidal, Jose Ernesto Braz J Infect Dis Case Report Osteomyelitis due to Cryptococcus neoformans are described in mostly 10% of patients with disseminated cryptococcosis, being direct inoculation even more uncommon. We report the case of an HIV-infected patient with history of recurring itching on his scalp and repetitive local trauma. For eighteen months, he noticed a painful and slow growing lump on his scalp. He was submitted to an excisional biopsy of the lesion but no etiological diagnosis was identified. After this procedure, the post-surgical wound never completely healed. At admission, the patient presented nausea and headache for three days and an open orifice into his skull. Investigations confirmed meningitis and skull osteomyelitis caused by Cryptococcus neoformans. He was treated with bone debridement and combined systemic antifungals, showing good clinical and laboratorial outcome. Cryptococcal disease should be included in the differential diagnoses of chronic osteomyelitis in HIV-infected patients and trauma is a possible source of infection. Elsevier 2018-12-06 /pmc/articles/PMC9425647/ /pubmed/30528189 http://dx.doi.org/10.1016/j.bjid.2018.11.004 Text en © 2018 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Adiwardana, Natanael Sutikno Morás, Juliana de Angelo Bernardo, Leandro Lombo Klautau, Giselle Burlamaqui Queiroz, Wladimir Vidal, Jose Ernesto Chronic skull osteomyelitis due to Cryptococcus neoformans: first case report in an HIV-infected patient |
title | Chronic skull osteomyelitis due to Cryptococcus neoformans: first case report in an HIV-infected patient |
title_full | Chronic skull osteomyelitis due to Cryptococcus neoformans: first case report in an HIV-infected patient |
title_fullStr | Chronic skull osteomyelitis due to Cryptococcus neoformans: first case report in an HIV-infected patient |
title_full_unstemmed | Chronic skull osteomyelitis due to Cryptococcus neoformans: first case report in an HIV-infected patient |
title_short | Chronic skull osteomyelitis due to Cryptococcus neoformans: first case report in an HIV-infected patient |
title_sort | chronic skull osteomyelitis due to cryptococcus neoformans: first case report in an hiv-infected patient |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425647/ https://www.ncbi.nlm.nih.gov/pubmed/30528189 http://dx.doi.org/10.1016/j.bjid.2018.11.004 |
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