A case report of refractory angina in a patient with diabetes and apical hypertrophic cardiomyopathy

BACKGROUND: Using serial imaging over time, this case reviews the natural history of co-morbid Type two diabetes (T2D) and apical hypertrophic cardiomyopathy (HCM) and assesses the potential combined impact on myocardial structure and perfusion. CASE SUMMARY: A 59-year-old patient with concomitant T...

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Autores principales: Jex, Nicholas, Chowdhary, Amrit, Thirunavukarasu, Sharmaine, Levelt, Eylem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425848/
https://www.ncbi.nlm.nih.gov/pubmed/36045647
http://dx.doi.org/10.1093/ehjcr/ytac347
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author Jex, Nicholas
Chowdhary, Amrit
Thirunavukarasu, Sharmaine
Levelt, Eylem
author_facet Jex, Nicholas
Chowdhary, Amrit
Thirunavukarasu, Sharmaine
Levelt, Eylem
author_sort Jex, Nicholas
collection PubMed
description BACKGROUND: Using serial imaging over time, this case reviews the natural history of co-morbid Type two diabetes (T2D) and apical hypertrophic cardiomyopathy (HCM) and assesses the potential combined impact on myocardial structure and perfusion. CASE SUMMARY: A 59-year-old patient with concomitant T2D and an apical phenotype of HCM was seen over a 11-year period with a significant burden of anginal chest pain. Chest pain was refractory to anti-anginal medical therapy and persisted at on-going follow-up. Multi-modality imaging demonstrated significant deterioration in coronary microvascular function and increased myocardial scar burden despite unobstructed epicardial coronary arteries. DISCUSSION: Comorbidity with T2D and apical HCM resulted in a significant increase in myocardial fibrosis and deterioration in coronary microvascular function.
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spelling pubmed-94258482022-08-30 A case report of refractory angina in a patient with diabetes and apical hypertrophic cardiomyopathy Jex, Nicholas Chowdhary, Amrit Thirunavukarasu, Sharmaine Levelt, Eylem Eur Heart J Case Rep Case Report BACKGROUND: Using serial imaging over time, this case reviews the natural history of co-morbid Type two diabetes (T2D) and apical hypertrophic cardiomyopathy (HCM) and assesses the potential combined impact on myocardial structure and perfusion. CASE SUMMARY: A 59-year-old patient with concomitant T2D and an apical phenotype of HCM was seen over a 11-year period with a significant burden of anginal chest pain. Chest pain was refractory to anti-anginal medical therapy and persisted at on-going follow-up. Multi-modality imaging demonstrated significant deterioration in coronary microvascular function and increased myocardial scar burden despite unobstructed epicardial coronary arteries. DISCUSSION: Comorbidity with T2D and apical HCM resulted in a significant increase in myocardial fibrosis and deterioration in coronary microvascular function. Oxford University Press 2022-08-16 /pmc/articles/PMC9425848/ /pubmed/36045647 http://dx.doi.org/10.1093/ehjcr/ytac347 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Jex, Nicholas
Chowdhary, Amrit
Thirunavukarasu, Sharmaine
Levelt, Eylem
A case report of refractory angina in a patient with diabetes and apical hypertrophic cardiomyopathy
title A case report of refractory angina in a patient with diabetes and apical hypertrophic cardiomyopathy
title_full A case report of refractory angina in a patient with diabetes and apical hypertrophic cardiomyopathy
title_fullStr A case report of refractory angina in a patient with diabetes and apical hypertrophic cardiomyopathy
title_full_unstemmed A case report of refractory angina in a patient with diabetes and apical hypertrophic cardiomyopathy
title_short A case report of refractory angina in a patient with diabetes and apical hypertrophic cardiomyopathy
title_sort case report of refractory angina in a patient with diabetes and apical hypertrophic cardiomyopathy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425848/
https://www.ncbi.nlm.nih.gov/pubmed/36045647
http://dx.doi.org/10.1093/ehjcr/ytac347
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