Breast Metaplastic Carcinoma With Osteosarcomatous Differentiation: A Case Report and literature Review

Metaplastic breast carcinoma (MBCs) is a rare heterogeneous group of malignancies. Herein, we report a case of metaplastic breast carcinoma, which had 2 components. One of them was typical invasive ductal carcinoma (IDC), the other one was presenting as osteosarcoma with lots of immature trabeculae....

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Autores principales: Yang, Xue, Chen, Ling, Shen, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425891/
https://www.ncbi.nlm.nih.gov/pubmed/36051653
http://dx.doi.org/10.1177/2632010X221118056
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author Yang, Xue
Chen, Ling
Shen, Yan
author_facet Yang, Xue
Chen, Ling
Shen, Yan
author_sort Yang, Xue
collection PubMed
description Metaplastic breast carcinoma (MBCs) is a rare heterogeneous group of malignancies. Herein, we report a case of metaplastic breast carcinoma, which had 2 components. One of them was typical invasive ductal carcinoma (IDC), the other one was presenting as osteosarcoma with lots of immature trabeculae. The results of immunohistochemistry showed different presentations between them. The majority of MBCs show triple-negativity for ER, PR, and HER-2 and are thus associated with poor prognosis. Our report shows that, it is necessary to describe the proportion of the components and the presentations of immunohistochemistry in the diagnosis, which will be important to develop specific and effective therapies.
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spelling pubmed-94258912022-08-31 Breast Metaplastic Carcinoma With Osteosarcomatous Differentiation: A Case Report and literature Review Yang, Xue Chen, Ling Shen, Yan Clin Pathol Case Report Metaplastic breast carcinoma (MBCs) is a rare heterogeneous group of malignancies. Herein, we report a case of metaplastic breast carcinoma, which had 2 components. One of them was typical invasive ductal carcinoma (IDC), the other one was presenting as osteosarcoma with lots of immature trabeculae. The results of immunohistochemistry showed different presentations between them. The majority of MBCs show triple-negativity for ER, PR, and HER-2 and are thus associated with poor prognosis. Our report shows that, it is necessary to describe the proportion of the components and the presentations of immunohistochemistry in the diagnosis, which will be important to develop specific and effective therapies. SAGE Publications 2022-08-25 /pmc/articles/PMC9425891/ /pubmed/36051653 http://dx.doi.org/10.1177/2632010X221118056 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Yang, Xue
Chen, Ling
Shen, Yan
Breast Metaplastic Carcinoma With Osteosarcomatous Differentiation: A Case Report and literature Review
title Breast Metaplastic Carcinoma With Osteosarcomatous Differentiation: A Case Report and literature Review
title_full Breast Metaplastic Carcinoma With Osteosarcomatous Differentiation: A Case Report and literature Review
title_fullStr Breast Metaplastic Carcinoma With Osteosarcomatous Differentiation: A Case Report and literature Review
title_full_unstemmed Breast Metaplastic Carcinoma With Osteosarcomatous Differentiation: A Case Report and literature Review
title_short Breast Metaplastic Carcinoma With Osteosarcomatous Differentiation: A Case Report and literature Review
title_sort breast metaplastic carcinoma with osteosarcomatous differentiation: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425891/
https://www.ncbi.nlm.nih.gov/pubmed/36051653
http://dx.doi.org/10.1177/2632010X221118056
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AT chenling breastmetaplasticcarcinomawithosteosarcomatousdifferentiationacasereportandliteraturereview
AT shenyan breastmetaplasticcarcinomawithosteosarcomatousdifferentiationacasereportandliteraturereview

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