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The effect of general anesthesia on the test–retest reliability of resting-state fMRI metrics and optimization of scan length

Resting-state functional magnetic resonance imaging (rs-fMRI) has been known as a powerful tool in neuroscience. However, exploring the test–retest reliability of the metrics derived from the rs-fMRI BOLD signal is essential, particularly in the studies of patients with neurological disorders. Here,...

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Autores principales: Vedaei, Faezeh, Alizadeh, Mahdi, Romo, Victor, Mohamed, Feroze B., Wu, Chengyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425911/
https://www.ncbi.nlm.nih.gov/pubmed/36051647
http://dx.doi.org/10.3389/fnins.2022.937172
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author Vedaei, Faezeh
Alizadeh, Mahdi
Romo, Victor
Mohamed, Feroze B.
Wu, Chengyuan
author_facet Vedaei, Faezeh
Alizadeh, Mahdi
Romo, Victor
Mohamed, Feroze B.
Wu, Chengyuan
author_sort Vedaei, Faezeh
collection PubMed
description Resting-state functional magnetic resonance imaging (rs-fMRI) has been known as a powerful tool in neuroscience. However, exploring the test–retest reliability of the metrics derived from the rs-fMRI BOLD signal is essential, particularly in the studies of patients with neurological disorders. Here, two factors, namely, the effect of anesthesia and scan length, have been estimated on the reliability of rs-fMRI measurements. A total of nine patients with drug-resistant epilepsy (DRE) requiring interstitial thermal therapy (LITT) were scanned in two states. The first scan was performed in an awake state before surgery on the same patient. The second scan was performed 2 weeks later under general anesthesia necessary for LITT surgery. At each state, two rs-fMRI sessions were obtained that each one lasted 15 min, and the effect of scan length was evaluated. Voxel-wise rs-fMRI metrics, including the amplitude of low-frequency fluctuation (ALFF), the fractional amplitude of low-frequency fluctuation (fALFF), functional connectivity (FC), and regional homogeneity (ReHo), were measured. Intraclass correlation coefficient (ICC) was calculated to estimate the reliability of the measurements in two states of awake and under anesthesia. Overall, it appeared that the reliability of rs-fMRI metrics improved under anesthesia. From the 15-min data, we found mean ICC values in awake state including 0.81, 0.51, 0.65, and 0.84 for ALFF, fALFF, FC, and ReHo, respectively, as well as 0.80, 0.59, 0.83, and 0.88 for ALFF, fALFF, FC, and ReHo, respectively, under anesthesia. Additionally, our findings revealed that reliability increases as the function of scan length. We showed that the optimized scan length to achieve less variability of rs-fMRI measurements was 3.1–7.5 min shorter in an anesthetized, compared to a wakeful state.
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spelling pubmed-94259112022-08-31 The effect of general anesthesia on the test–retest reliability of resting-state fMRI metrics and optimization of scan length Vedaei, Faezeh Alizadeh, Mahdi Romo, Victor Mohamed, Feroze B. Wu, Chengyuan Front Neurosci Neuroscience Resting-state functional magnetic resonance imaging (rs-fMRI) has been known as a powerful tool in neuroscience. However, exploring the test–retest reliability of the metrics derived from the rs-fMRI BOLD signal is essential, particularly in the studies of patients with neurological disorders. Here, two factors, namely, the effect of anesthesia and scan length, have been estimated on the reliability of rs-fMRI measurements. A total of nine patients with drug-resistant epilepsy (DRE) requiring interstitial thermal therapy (LITT) were scanned in two states. The first scan was performed in an awake state before surgery on the same patient. The second scan was performed 2 weeks later under general anesthesia necessary for LITT surgery. At each state, two rs-fMRI sessions were obtained that each one lasted 15 min, and the effect of scan length was evaluated. Voxel-wise rs-fMRI metrics, including the amplitude of low-frequency fluctuation (ALFF), the fractional amplitude of low-frequency fluctuation (fALFF), functional connectivity (FC), and regional homogeneity (ReHo), were measured. Intraclass correlation coefficient (ICC) was calculated to estimate the reliability of the measurements in two states of awake and under anesthesia. Overall, it appeared that the reliability of rs-fMRI metrics improved under anesthesia. From the 15-min data, we found mean ICC values in awake state including 0.81, 0.51, 0.65, and 0.84 for ALFF, fALFF, FC, and ReHo, respectively, as well as 0.80, 0.59, 0.83, and 0.88 for ALFF, fALFF, FC, and ReHo, respectively, under anesthesia. Additionally, our findings revealed that reliability increases as the function of scan length. We showed that the optimized scan length to achieve less variability of rs-fMRI measurements was 3.1–7.5 min shorter in an anesthetized, compared to a wakeful state. Frontiers Media S.A. 2022-08-16 /pmc/articles/PMC9425911/ /pubmed/36051647 http://dx.doi.org/10.3389/fnins.2022.937172 Text en Copyright © 2022 Vedaei, Alizadeh, Romo, Mohamed and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Vedaei, Faezeh
Alizadeh, Mahdi
Romo, Victor
Mohamed, Feroze B.
Wu, Chengyuan
The effect of general anesthesia on the test–retest reliability of resting-state fMRI metrics and optimization of scan length
title The effect of general anesthesia on the test–retest reliability of resting-state fMRI metrics and optimization of scan length
title_full The effect of general anesthesia on the test–retest reliability of resting-state fMRI metrics and optimization of scan length
title_fullStr The effect of general anesthesia on the test–retest reliability of resting-state fMRI metrics and optimization of scan length
title_full_unstemmed The effect of general anesthesia on the test–retest reliability of resting-state fMRI metrics and optimization of scan length
title_short The effect of general anesthesia on the test–retest reliability of resting-state fMRI metrics and optimization of scan length
title_sort effect of general anesthesia on the test–retest reliability of resting-state fmri metrics and optimization of scan length
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425911/
https://www.ncbi.nlm.nih.gov/pubmed/36051647
http://dx.doi.org/10.3389/fnins.2022.937172
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