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Choroidal and retinal thickness variations in ocular albinism

PURPOSE: To study the retinal and choroidal thickness variations on enhanced depth imaging optical coherence tomography scans in ocular albinism (OA) and compare with age-matched healthy subjects. METHODS: This retrospective observational study had 48 eyes of 24 patients diagnosed clinically as OA a...

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Autores principales: Venkatesh, Ramesh, Agrawal, Sameeksha, Reddy, Nikitha Gurram, Sridharan, Akhila, Ong, Joshua, Yadav, Naresh Kumar, Chhablani, Jay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426091/
https://www.ncbi.nlm.nih.gov/pubmed/35791146
http://dx.doi.org/10.4103/ijo.IJO_2907_21
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author Venkatesh, Ramesh
Agrawal, Sameeksha
Reddy, Nikitha Gurram
Sridharan, Akhila
Ong, Joshua
Yadav, Naresh Kumar
Chhablani, Jay
author_facet Venkatesh, Ramesh
Agrawal, Sameeksha
Reddy, Nikitha Gurram
Sridharan, Akhila
Ong, Joshua
Yadav, Naresh Kumar
Chhablani, Jay
author_sort Venkatesh, Ramesh
collection PubMed
description PURPOSE: To study the retinal and choroidal thickness variations on enhanced depth imaging optical coherence tomography scans in ocular albinism (OA) and compare with age-matched healthy subjects. METHODS: This retrospective observational study had 48 eyes of 24 patients diagnosed clinically as OA and age, sex, and axial length-matched control healthy subjects. All patients underwent detailed ophthalmic examination and a single-line horizontal-raster enhanced depth imaging – optical coherence tomography scan (Spectralis, Heidelberg Engineering). Retinal and choroidal thickness was measured, compared, and analyzed between the two groups. Mann–Whitney U test was used for analysis between the two groups. P < 0.05 was considered significant. RESULTS: The mean age was 28.3 ± 11.6 and 29.9 ± 10.6 years in the OA group and control group, respectively. Spherical equivalents ranged from −8.5D to +10.5D in the OA group and from −8.0D to +10.0D in the control group. The mean axial length between the two groups (P = 0.652) were comparable. The average retinal thickness (272 ± 34.3 vs. 213 ± 13.8 mm; P < 0.001) was greater in the OA group as compared to controls. The mean choroidal thickness (184 ± 78.4 vs. 287 ± 46.4 mm; P < 0.001) was significantly thinner in the OA group. CONCLUSION: Acquisition of OCT scans in OA can be challenging. This study showed that the subfoveal retinal thickness and choroidal thickness measured across the scans were significantly different in the OA group compared to controls. In the future, more studies are required to evaluate the role of the choroid and its relationship to emmetropization in albinism.
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spelling pubmed-94260912022-08-31 Choroidal and retinal thickness variations in ocular albinism Venkatesh, Ramesh Agrawal, Sameeksha Reddy, Nikitha Gurram Sridharan, Akhila Ong, Joshua Yadav, Naresh Kumar Chhablani, Jay Indian J Ophthalmol Original Article PURPOSE: To study the retinal and choroidal thickness variations on enhanced depth imaging optical coherence tomography scans in ocular albinism (OA) and compare with age-matched healthy subjects. METHODS: This retrospective observational study had 48 eyes of 24 patients diagnosed clinically as OA and age, sex, and axial length-matched control healthy subjects. All patients underwent detailed ophthalmic examination and a single-line horizontal-raster enhanced depth imaging – optical coherence tomography scan (Spectralis, Heidelberg Engineering). Retinal and choroidal thickness was measured, compared, and analyzed between the two groups. Mann–Whitney U test was used for analysis between the two groups. P < 0.05 was considered significant. RESULTS: The mean age was 28.3 ± 11.6 and 29.9 ± 10.6 years in the OA group and control group, respectively. Spherical equivalents ranged from −8.5D to +10.5D in the OA group and from −8.0D to +10.0D in the control group. The mean axial length between the two groups (P = 0.652) were comparable. The average retinal thickness (272 ± 34.3 vs. 213 ± 13.8 mm; P < 0.001) was greater in the OA group as compared to controls. The mean choroidal thickness (184 ± 78.4 vs. 287 ± 46.4 mm; P < 0.001) was significantly thinner in the OA group. CONCLUSION: Acquisition of OCT scans in OA can be challenging. This study showed that the subfoveal retinal thickness and choroidal thickness measured across the scans were significantly different in the OA group compared to controls. In the future, more studies are required to evaluate the role of the choroid and its relationship to emmetropization in albinism. Wolters Kluwer - Medknow 2022-07 2022-06-30 /pmc/articles/PMC9426091/ /pubmed/35791146 http://dx.doi.org/10.4103/ijo.IJO_2907_21 Text en Copyright: © 2022 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Venkatesh, Ramesh
Agrawal, Sameeksha
Reddy, Nikitha Gurram
Sridharan, Akhila
Ong, Joshua
Yadav, Naresh Kumar
Chhablani, Jay
Choroidal and retinal thickness variations in ocular albinism
title Choroidal and retinal thickness variations in ocular albinism
title_full Choroidal and retinal thickness variations in ocular albinism
title_fullStr Choroidal and retinal thickness variations in ocular albinism
title_full_unstemmed Choroidal and retinal thickness variations in ocular albinism
title_short Choroidal and retinal thickness variations in ocular albinism
title_sort choroidal and retinal thickness variations in ocular albinism
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426091/
https://www.ncbi.nlm.nih.gov/pubmed/35791146
http://dx.doi.org/10.4103/ijo.IJO_2907_21
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