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Inhibition of nonhomologous end joining‐mediated DNA repair enhances anti‐HBV CRISPR therapy

Current anti–hepatitis B virus (HBV) therapies have little effect on covalently closed circular DNA (cccDNA) and fail to eliminate HBV. The clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system has been reported to directly target cccDNA and exert antiviral effects. In this s...

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Detalles Bibliográficos
Autores principales:	Murai, Kazuhiro, Kodama, Takahiro, Hikita, Hayato, Shimoda, Akiyoshi, Fukuoka, Makoto, Fukutomi, Keisuke, Shigeno, Satoshi, Shiode, Yuto, Motooka, Daisuke, Higuchi, Yuichiro, Miyakawa, Kei, Suemizu, Hiroshi, Ryo, Akihide, Tahata, Yuki, Makino, Yuki, Yamada, Ryoko, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426388/ https://www.ncbi.nlm.nih.gov/pubmed/35608131 http://dx.doi.org/10.1002/hep4.2014

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