Tetrahydroxylated bile acids improve cholestatic liver and bile duct injury in the Mdr2(−/−) mouse model of sclerosing cholangitis via immunomodulatory effects

Bile salt export pump (Bsep) (Abcb11)( −/− ) mice are protected from acquired cholestatic injury due to metabolic preconditioning with a hydrophilic bile acid (BA) pool with formation of tetrahydroxylated bile acids (THBAs). We aimed to explore whether loss of Bsep and subsequent elevation of THBA l...

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Detalles Bibliográficos
Autores principales: Fuchs, Claudia D., Dixon, Emmanuel D., Hendrikx, Tim, Mlitz, Veronika, Wahlström, Annika, Ståhlman, Marcus, Scharnagl, Hubert, Stojakovic, Tatjana, Binder, Christoph J., Marschall, Hanns‐Ulrich, Trauner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426398/
https://www.ncbi.nlm.nih.gov/pubmed/35691019
http://dx.doi.org/10.1002/hep4.1998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426398/
https://www.ncbi.nlm.nih.gov/pubmed/35691019
http://dx.doi.org/10.1002/hep4.1998

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