Cargando…

Combinations of an acetyl CoA carboxylase inhibitor with hepatic lipid modulating agents do not augment antifibrotic efficacy in preclinical models of NASH and fibrosis

Dysregulated hepatocyte lipid metabolism is a hallmark of hepatic lipotoxicity and contributes to the pathogenesis of nonalcoholic steatohepatitis (NASH). Acetyl CoA carboxylase (ACC) inhibitors decrease hepatocyte lipotoxicity by inhibiting de novo lipogenesis and concomitantly increasing fatty aci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vijayakumar, Archana, Okesli‐Armlovich, Ayse, Wang, Ting, Olson, Isabel, Seung, Minji, Kusam, Saritha, Hollenback, David, Mahadevan, Sangeetha, Marchand, Bruno, Toteva, Maria, Breckenridge, David G., Trevaskis, James L., Bates, Jamie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426400/ https://www.ncbi.nlm.nih.gov/pubmed/35735253 http://dx.doi.org/10.1002/hep4.2011

Ejemplares similares

Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems
por: Ross, Trenton T., et al.
Publicado: (2020)

Acetyl-CoA Carboxylases and Diseases
por: Wang, Yu, et al.
Publicado: (2022)

WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice
por: Gao, Ying-sheng, et al.
Publicado: (2019)

Chemical Genetics of Acetyl-CoA Carboxylases
por: Zu, Xuyu, et al.
Publicado: (2013)

Acetyl-CoA carboxylase inhibitor increases LDL-apoB production rate in NASH with cirrhosis: prevention by fenofibrate
por: Dandan, Mohamad, et al.
Publicado: (2023)

The dynamic organization of fungal acetyl-CoA carboxylase
por: Hunkeler, Moritz, et al.
Publicado: (2016)

Efficacy and safety of acetyl-CoA carboxylase (ACC) inhibitors in the treatment of nonalcoholic steatohepatitis (NASH): A protocol for systematic review
por: Xu, Liubin, et al.
Publicado: (2022)

Dynamics of the Degradation of Acetyl-CoA Carboxylase Herbicides in Vegetables
por: Jursík, Miroslav, et al.
Publicado: (2021)

Targeting acetyl-CoA carboxylase 1 for cancer therapy
por: Yu, Yong, et al.
Publicado: (2023)

Acetyl-CoA Carboxylase Inhibition as a Therapeutic Tool in the Battle Against NASH: Hitting More Than Just One Mechanism?
por: Lambrecht, Joeri, et al.
Publicado: (2020)

Acetyl CoA Carboxylase 2 Is Dispensable for CD8(+) T Cell Responses
por: Lee, Jang Eun, et al.
Publicado: (2015)

Characterization of Acetyl-CoA Carboxylases in the Basal Dinoflagellate Amphidinium carterae
por: Haq, Saddef, et al.
Publicado: (2017)

Pyrrolocin C and equisetin inhibit bacterial acetyl-CoA carboxylase
por: Larson, Erica C., et al.
Publicado: (2020)

Alternative polyadenylation regulates acetyl-CoA carboxylase function in peanut
por: Peng, Zhenying, et al.
Publicado: (2023)

Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program
por: Guilherme, Adilson, et al.
Publicado: (2023)

Sequences of acetyl CoA carboxylase promoter for tumour necrosis factor action
por: Park, Keerang, et al.
Publicado: (1993)

Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis
por: Unissa, Ameeruddin Nusrath, et al.
Publicado: (2011)

A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation
por: Wei, Jia, et al.
Publicado: (2016)

A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation
por: Wei, Jia, et al.
Publicado: (2017)

Acetyl-CoA carboxylase inhibitors in non-alcoholic steatohepatitis: Is there a benefit?
por: Neokosmidis, Georgios, et al.
Publicado: (2021)

Biochemical and structural characterization of quizalofop-resistant wheat acetyl-CoA carboxylase
por: Bough, Raven, et al.
Publicado: (2022)

Comparative RNA-sequencing profiled the differential gene expression of liver in response to acetyl-CoA carboxylase inhibitor GS-0976 in a mouse model of NASH
por: Lu, Ying, et al.
Publicado: (2019)

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation()
por: Chow, Jenny D.Y., et al.
Publicado: (2014)

The role of acetyl-coA carboxylase2 in head and neck squamous cell carcinoma
por: Li, Kun, et al.
Publicado: (2019)

Acetyl-CoA carboxylase 1–dependent lipogenesis promotes autophagy downstream of AMPK
por: Gross, Angelina S., et al.
Publicado: (2019)

Inhibition of acetyl-CoA carboxylase impaired tubulin palmitoylation and induced spindle abnormalities
por: Fang, Chieh-Ting, et al.
Publicado: (2023)

Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase 1 and De novo Lipogenesis
por: Scott, Kristen E. N., et al.
Publicado: (2012)

Phylogenetic Analysis of Nucleus-Encoded Acetyl-CoA Carboxylases Targeted at the Cytosol and Plastid of Algae
por: Huerlimann, Roger, et al.
Publicado: (2015)

Underlying Resistance Mechanisms in the Cynosurus echinatus Biotype to Acetyl CoA Carboxylase-Inhibiting Herbicides
por: Fernández, Pablo, et al.
Publicado: (2016)

Crystal structure of the 500 kD yeast acetyl-CoA carboxylase holoenzyme dimer
por: Wei, Jia, et al.
Publicado: (2015)

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis
por: Galic, Sandra, et al.
Publicado: (2018)

Inhibition of acetyl-CoA carboxylase by spirotetramat causes growth arrest and lipid depletion in nematodes
por: Gutbrod, Philipp, et al.
Publicado: (2020)

Expression of Yarrowia lipolytica acetyl-CoA carboxylase in Saccharomyces cerevisiae and its effect on in-vivo accumulation of Malonyl-CoA
por: Pereira, Humberto, et al.
Publicado: (2022)

Acetyl-CoA Carboxylase Inhibitor CP640.186 Increases Tubulin Acetylation and Impairs Thrombin-Induced Platelet Aggregation
por: Octave, Marie, et al.
Publicado: (2021)

Screening Phosphorylation Site Mutations in Yeast Acetyl-CoA Carboxylase Using Malonyl-CoA Sensor to Improve Malonyl-CoA-Derived Product
por: Chen, Xiaoxu, et al.
Publicado: (2018)

Aberrant mitosis in fission yeast mutants defective in fatty acid synthetase and acetyl CoA carboxylase
Publicado: (1996)

Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells
por: Corominas-Faja, Bruna, et al.
Publicado: (2014)

Acetyl-CoA carboxylase inhibitors attenuate WNT and Hedgehog signaling and suppress pancreatic tumor growth
por: Petrova, Elissaveta, et al.
Publicado: (2016)

Synthesis and biological evaluation of 4-phenoxy-phenyl isoxazoles as novel acetyl-CoA carboxylase inhibitors
por: Wu, Xin, et al.
Publicado: (2021)

Docking of acetyl-CoA carboxylase to the plastid envelope membrane attenuates fatty acid production in plants
por: Ye, Yajin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bpa00pooqk2giu0v4033kkf074