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Mid‐upper arm circumference is associated with liver steatosis and fibrosis in patients with metabolic‐associated fatty liver disease: A population based observational study
Metabolic‐associated fatty liver disease (MAFLD) is a series of liver diseases based on liver steatosis and metabolic disorders. Steatosis, as the core factor in MAFLD diagnosis, and fibrosis, as the major determinant of adverse outcomes of MAFLD, need to be assessed simply and accurately. In this s...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426403/ https://www.ncbi.nlm.nih.gov/pubmed/35560825 http://dx.doi.org/10.1002/hep4.1990 |
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author | Wang, Xiaoxiao Li, Xiaohe Jin, Rui Yang, Jia Huang, Rui Wei, Lai Liu, Feng Rao, Huiying |
author_facet | Wang, Xiaoxiao Li, Xiaohe Jin, Rui Yang, Jia Huang, Rui Wei, Lai Liu, Feng Rao, Huiying |
author_sort | Wang, Xiaoxiao |
collection | PubMed |
description | Metabolic‐associated fatty liver disease (MAFLD) is a series of liver diseases based on liver steatosis and metabolic disorders. Steatosis, as the core factor in MAFLD diagnosis, and fibrosis, as the major determinant of adverse outcomes of MAFLD, need to be assessed simply and accurately. In this study, we explored the significance of mid‐upper arm circumference (MUAC) in evaluating liver steatosis and fibrosis in patients with MAFLD. We included 2397 cases with MAFLD from the 2017–2018 National Health and Nutrition Examination Surveys (NHANES) database. Liver steatosis and fibrosis were measured by vibration controlled transient elastography. Anthropometric parameters and demographic and serological data were obtained from the NHANES database. The association between MUAC and liver steatosis and fibrosis were evaluated by a multivariable linear regression model, a weighted generalized additive model, and smooth curve fitting using R. MUAC was positively associated with liver steatosis in every multivariate linear regression model (model 1: β = 3.3513; 95% confidence interval [CI], 2.7722–3.9304; model 2: β = 3.8492; 95% CI, 3.2441–4.4542; model 3: β = 2.4987; 95% CI, 1.8371–3.1604), and this positive association was consistent in both men and women and among different race groups (Mexican American, other Hispanic, non‐Hispanic White, Black, Asian, and other race). On the other hand, MUAC was positively associated with liver fibrosis in every multivariate linear regression model, and this positive association also was consistent in both men and women and among non‐Hispanic White and Black populations. Increased MUAC was positively associated with liver steatosis and fibrosis in patients with MAFLD. This was particularly true for MUAC ≥ 42.0 cm. MUAC might be a simple and convenient evaluation tool for MAFLD. |
format | Online Article Text |
id | pubmed-9426403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94264032022-08-31 Mid‐upper arm circumference is associated with liver steatosis and fibrosis in patients with metabolic‐associated fatty liver disease: A population based observational study Wang, Xiaoxiao Li, Xiaohe Jin, Rui Yang, Jia Huang, Rui Wei, Lai Liu, Feng Rao, Huiying Hepatol Commun Original Articles Metabolic‐associated fatty liver disease (MAFLD) is a series of liver diseases based on liver steatosis and metabolic disorders. Steatosis, as the core factor in MAFLD diagnosis, and fibrosis, as the major determinant of adverse outcomes of MAFLD, need to be assessed simply and accurately. In this study, we explored the significance of mid‐upper arm circumference (MUAC) in evaluating liver steatosis and fibrosis in patients with MAFLD. We included 2397 cases with MAFLD from the 2017–2018 National Health and Nutrition Examination Surveys (NHANES) database. Liver steatosis and fibrosis were measured by vibration controlled transient elastography. Anthropometric parameters and demographic and serological data were obtained from the NHANES database. The association between MUAC and liver steatosis and fibrosis were evaluated by a multivariable linear regression model, a weighted generalized additive model, and smooth curve fitting using R. MUAC was positively associated with liver steatosis in every multivariate linear regression model (model 1: β = 3.3513; 95% confidence interval [CI], 2.7722–3.9304; model 2: β = 3.8492; 95% CI, 3.2441–4.4542; model 3: β = 2.4987; 95% CI, 1.8371–3.1604), and this positive association was consistent in both men and women and among different race groups (Mexican American, other Hispanic, non‐Hispanic White, Black, Asian, and other race). On the other hand, MUAC was positively associated with liver fibrosis in every multivariate linear regression model, and this positive association also was consistent in both men and women and among non‐Hispanic White and Black populations. Increased MUAC was positively associated with liver steatosis and fibrosis in patients with MAFLD. This was particularly true for MUAC ≥ 42.0 cm. MUAC might be a simple and convenient evaluation tool for MAFLD. John Wiley and Sons Inc. 2022-05-13 /pmc/articles/PMC9426403/ /pubmed/35560825 http://dx.doi.org/10.1002/hep4.1990 Text en © 2022 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Wang, Xiaoxiao Li, Xiaohe Jin, Rui Yang, Jia Huang, Rui Wei, Lai Liu, Feng Rao, Huiying Mid‐upper arm circumference is associated with liver steatosis and fibrosis in patients with metabolic‐associated fatty liver disease: A population based observational study |
title | Mid‐upper arm circumference is associated with liver steatosis and fibrosis in patients with metabolic‐associated fatty liver disease: A population based observational study |
title_full | Mid‐upper arm circumference is associated with liver steatosis and fibrosis in patients with metabolic‐associated fatty liver disease: A population based observational study |
title_fullStr | Mid‐upper arm circumference is associated with liver steatosis and fibrosis in patients with metabolic‐associated fatty liver disease: A population based observational study |
title_full_unstemmed | Mid‐upper arm circumference is associated with liver steatosis and fibrosis in patients with metabolic‐associated fatty liver disease: A population based observational study |
title_short | Mid‐upper arm circumference is associated with liver steatosis and fibrosis in patients with metabolic‐associated fatty liver disease: A population based observational study |
title_sort | mid‐upper arm circumference is associated with liver steatosis and fibrosis in patients with metabolic‐associated fatty liver disease: a population based observational study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426403/ https://www.ncbi.nlm.nih.gov/pubmed/35560825 http://dx.doi.org/10.1002/hep4.1990 |
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