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Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population

Global population immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is accumulating through heterogeneous combinations of infection and vaccination. Vaccine distribution in low- and middle-income countries has been variable and reliant on diverse vaccine platforms. We studied...

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Autores principales: Bednarski, Eva, Del Rio Estrada, Perla M., DaSilva, Justin, Boukadida, Celia, Zhang, Fengwen, Luna-Villalobos, Yara A., Rodríguez-Rangel, Ximena, Pitén-Isidro, Elvira, Luna-García, Edgar, Díaz Rivera, Dafne, López-Sánchez, Dulce M., Tapia-Trejo, Daniela, Soto-Nava, Maribel, Astorga-Castañeda, Myriam, Martínez-Moreno, José O., Urbina-Granados, Guadalupe S., Jiménez-Jacinto, José A., Serna Alvarado, Francisco J., Enriquez-López, Yerania E., López-Arellano, Oliva, Reyes-Teran, Gustavo, Bieniasz, Paul D., Avila-Rios, Santiago, Hatziioannou, Theodora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426429/
https://www.ncbi.nlm.nih.gov/pubmed/35735743
http://dx.doi.org/10.1128/mbio.00840-22
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author Bednarski, Eva
Del Rio Estrada, Perla M.
DaSilva, Justin
Boukadida, Celia
Zhang, Fengwen
Luna-Villalobos, Yara A.
Rodríguez-Rangel, Ximena
Pitén-Isidro, Elvira
Luna-García, Edgar
Díaz Rivera, Dafne
López-Sánchez, Dulce M.
Tapia-Trejo, Daniela
Soto-Nava, Maribel
Astorga-Castañeda, Myriam
Martínez-Moreno, José O.
Urbina-Granados, Guadalupe S.
Jiménez-Jacinto, José A.
Serna Alvarado, Francisco J.
Enriquez-López, Yerania E.
López-Arellano, Oliva
Reyes-Teran, Gustavo
Bieniasz, Paul D.
Avila-Rios, Santiago
Hatziioannou, Theodora
author_facet Bednarski, Eva
Del Rio Estrada, Perla M.
DaSilva, Justin
Boukadida, Celia
Zhang, Fengwen
Luna-Villalobos, Yara A.
Rodríguez-Rangel, Ximena
Pitén-Isidro, Elvira
Luna-García, Edgar
Díaz Rivera, Dafne
López-Sánchez, Dulce M.
Tapia-Trejo, Daniela
Soto-Nava, Maribel
Astorga-Castañeda, Myriam
Martínez-Moreno, José O.
Urbina-Granados, Guadalupe S.
Jiménez-Jacinto, José A.
Serna Alvarado, Francisco J.
Enriquez-López, Yerania E.
López-Arellano, Oliva
Reyes-Teran, Gustavo
Bieniasz, Paul D.
Avila-Rios, Santiago
Hatziioannou, Theodora
author_sort Bednarski, Eva
collection PubMed
description Global population immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is accumulating through heterogeneous combinations of infection and vaccination. Vaccine distribution in low- and middle-income countries has been variable and reliant on diverse vaccine platforms. We studied B-cell immunity in Mexico, a middle-income country where five different vaccines have been deployed to populations with high SARS-CoV-2 incidences. Levels of antibodies that bound a stabilized prefusion spike trimer, neutralizing antibody titers, and memory B-cell expansion correlated with each other across vaccine platforms. Nevertheless, the vaccines elicited variable levels of B-cell immunity, and the majority of recipients had undetectable neutralizing activity against the recently emergent omicron variant. SARS-CoV-2 infection, experienced before or after vaccination, potentiated B-cell immune responses and enabled the generation of neutralizing activity against omicron and SARS-CoV for all vaccines in nearly all individuals. These findings suggest that broad population immunity to SARS-CoV-2 will eventually be achieved but by heterogeneous paths.
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spelling pubmed-94264292022-08-31 Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population Bednarski, Eva Del Rio Estrada, Perla M. DaSilva, Justin Boukadida, Celia Zhang, Fengwen Luna-Villalobos, Yara A. Rodríguez-Rangel, Ximena Pitén-Isidro, Elvira Luna-García, Edgar Díaz Rivera, Dafne López-Sánchez, Dulce M. Tapia-Trejo, Daniela Soto-Nava, Maribel Astorga-Castañeda, Myriam Martínez-Moreno, José O. Urbina-Granados, Guadalupe S. Jiménez-Jacinto, José A. Serna Alvarado, Francisco J. Enriquez-López, Yerania E. López-Arellano, Oliva Reyes-Teran, Gustavo Bieniasz, Paul D. Avila-Rios, Santiago Hatziioannou, Theodora mBio Research Article Global population immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is accumulating through heterogeneous combinations of infection and vaccination. Vaccine distribution in low- and middle-income countries has been variable and reliant on diverse vaccine platforms. We studied B-cell immunity in Mexico, a middle-income country where five different vaccines have been deployed to populations with high SARS-CoV-2 incidences. Levels of antibodies that bound a stabilized prefusion spike trimer, neutralizing antibody titers, and memory B-cell expansion correlated with each other across vaccine platforms. Nevertheless, the vaccines elicited variable levels of B-cell immunity, and the majority of recipients had undetectable neutralizing activity against the recently emergent omicron variant. SARS-CoV-2 infection, experienced before or after vaccination, potentiated B-cell immune responses and enabled the generation of neutralizing activity against omicron and SARS-CoV for all vaccines in nearly all individuals. These findings suggest that broad population immunity to SARS-CoV-2 will eventually be achieved but by heterogeneous paths. American Society for Microbiology 2022-06-23 /pmc/articles/PMC9426429/ /pubmed/35735743 http://dx.doi.org/10.1128/mbio.00840-22 Text en Copyright © 2022 Bednarski et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Bednarski, Eva
Del Rio Estrada, Perla M.
DaSilva, Justin
Boukadida, Celia
Zhang, Fengwen
Luna-Villalobos, Yara A.
Rodríguez-Rangel, Ximena
Pitén-Isidro, Elvira
Luna-García, Edgar
Díaz Rivera, Dafne
López-Sánchez, Dulce M.
Tapia-Trejo, Daniela
Soto-Nava, Maribel
Astorga-Castañeda, Myriam
Martínez-Moreno, José O.
Urbina-Granados, Guadalupe S.
Jiménez-Jacinto, José A.
Serna Alvarado, Francisco J.
Enriquez-López, Yerania E.
López-Arellano, Oliva
Reyes-Teran, Gustavo
Bieniasz, Paul D.
Avila-Rios, Santiago
Hatziioannou, Theodora
Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population
title Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population
title_full Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population
title_fullStr Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population
title_full_unstemmed Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population
title_short Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population
title_sort antibody and memory b-cell immunity in a heterogeneously sars-cov-2-infected and -vaccinated population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426429/
https://www.ncbi.nlm.nih.gov/pubmed/35735743
http://dx.doi.org/10.1128/mbio.00840-22
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