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Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population
Global population immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is accumulating through heterogeneous combinations of infection and vaccination. Vaccine distribution in low- and middle-income countries has been variable and reliant on diverse vaccine platforms. We studied...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Society for Microbiology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426429/ https://www.ncbi.nlm.nih.gov/pubmed/35735743 http://dx.doi.org/10.1128/mbio.00840-22 |
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author | Bednarski, Eva Del Rio Estrada, Perla M. DaSilva, Justin Boukadida, Celia Zhang, Fengwen Luna-Villalobos, Yara A. Rodríguez-Rangel, Ximena Pitén-Isidro, Elvira Luna-García, Edgar Díaz Rivera, Dafne López-Sánchez, Dulce M. Tapia-Trejo, Daniela Soto-Nava, Maribel Astorga-Castañeda, Myriam Martínez-Moreno, José O. Urbina-Granados, Guadalupe S. Jiménez-Jacinto, José A. Serna Alvarado, Francisco J. Enriquez-López, Yerania E. López-Arellano, Oliva Reyes-Teran, Gustavo Bieniasz, Paul D. Avila-Rios, Santiago Hatziioannou, Theodora |
author_facet | Bednarski, Eva Del Rio Estrada, Perla M. DaSilva, Justin Boukadida, Celia Zhang, Fengwen Luna-Villalobos, Yara A. Rodríguez-Rangel, Ximena Pitén-Isidro, Elvira Luna-García, Edgar Díaz Rivera, Dafne López-Sánchez, Dulce M. Tapia-Trejo, Daniela Soto-Nava, Maribel Astorga-Castañeda, Myriam Martínez-Moreno, José O. Urbina-Granados, Guadalupe S. Jiménez-Jacinto, José A. Serna Alvarado, Francisco J. Enriquez-López, Yerania E. López-Arellano, Oliva Reyes-Teran, Gustavo Bieniasz, Paul D. Avila-Rios, Santiago Hatziioannou, Theodora |
author_sort | Bednarski, Eva |
collection | PubMed |
description | Global population immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is accumulating through heterogeneous combinations of infection and vaccination. Vaccine distribution in low- and middle-income countries has been variable and reliant on diverse vaccine platforms. We studied B-cell immunity in Mexico, a middle-income country where five different vaccines have been deployed to populations with high SARS-CoV-2 incidences. Levels of antibodies that bound a stabilized prefusion spike trimer, neutralizing antibody titers, and memory B-cell expansion correlated with each other across vaccine platforms. Nevertheless, the vaccines elicited variable levels of B-cell immunity, and the majority of recipients had undetectable neutralizing activity against the recently emergent omicron variant. SARS-CoV-2 infection, experienced before or after vaccination, potentiated B-cell immune responses and enabled the generation of neutralizing activity against omicron and SARS-CoV for all vaccines in nearly all individuals. These findings suggest that broad population immunity to SARS-CoV-2 will eventually be achieved but by heterogeneous paths. |
format | Online Article Text |
id | pubmed-9426429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-94264292022-08-31 Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population Bednarski, Eva Del Rio Estrada, Perla M. DaSilva, Justin Boukadida, Celia Zhang, Fengwen Luna-Villalobos, Yara A. Rodríguez-Rangel, Ximena Pitén-Isidro, Elvira Luna-García, Edgar Díaz Rivera, Dafne López-Sánchez, Dulce M. Tapia-Trejo, Daniela Soto-Nava, Maribel Astorga-Castañeda, Myriam Martínez-Moreno, José O. Urbina-Granados, Guadalupe S. Jiménez-Jacinto, José A. Serna Alvarado, Francisco J. Enriquez-López, Yerania E. López-Arellano, Oliva Reyes-Teran, Gustavo Bieniasz, Paul D. Avila-Rios, Santiago Hatziioannou, Theodora mBio Research Article Global population immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is accumulating through heterogeneous combinations of infection and vaccination. Vaccine distribution in low- and middle-income countries has been variable and reliant on diverse vaccine platforms. We studied B-cell immunity in Mexico, a middle-income country where five different vaccines have been deployed to populations with high SARS-CoV-2 incidences. Levels of antibodies that bound a stabilized prefusion spike trimer, neutralizing antibody titers, and memory B-cell expansion correlated with each other across vaccine platforms. Nevertheless, the vaccines elicited variable levels of B-cell immunity, and the majority of recipients had undetectable neutralizing activity against the recently emergent omicron variant. SARS-CoV-2 infection, experienced before or after vaccination, potentiated B-cell immune responses and enabled the generation of neutralizing activity against omicron and SARS-CoV for all vaccines in nearly all individuals. These findings suggest that broad population immunity to SARS-CoV-2 will eventually be achieved but by heterogeneous paths. American Society for Microbiology 2022-06-23 /pmc/articles/PMC9426429/ /pubmed/35735743 http://dx.doi.org/10.1128/mbio.00840-22 Text en Copyright © 2022 Bednarski et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Bednarski, Eva Del Rio Estrada, Perla M. DaSilva, Justin Boukadida, Celia Zhang, Fengwen Luna-Villalobos, Yara A. Rodríguez-Rangel, Ximena Pitén-Isidro, Elvira Luna-García, Edgar Díaz Rivera, Dafne López-Sánchez, Dulce M. Tapia-Trejo, Daniela Soto-Nava, Maribel Astorga-Castañeda, Myriam Martínez-Moreno, José O. Urbina-Granados, Guadalupe S. Jiménez-Jacinto, José A. Serna Alvarado, Francisco J. Enriquez-López, Yerania E. López-Arellano, Oliva Reyes-Teran, Gustavo Bieniasz, Paul D. Avila-Rios, Santiago Hatziioannou, Theodora Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population |
title | Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population |
title_full | Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population |
title_fullStr | Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population |
title_full_unstemmed | Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population |
title_short | Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population |
title_sort | antibody and memory b-cell immunity in a heterogeneously sars-cov-2-infected and -vaccinated population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426429/ https://www.ncbi.nlm.nih.gov/pubmed/35735743 http://dx.doi.org/10.1128/mbio.00840-22 |
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