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Genetic Interaction Analysis Reveals that Cryptococcus neoformans Utilizes Multiple Acetyl-CoA-Generating Pathways during Infection

Cryptococcus neoformans is an important human fungal pathogen for which the external environment is its primary niche. Previous work has shown that two nonessential acetyl-CoA metabolism enzymes, ATP-citrate lyase (ACL1) and acetyl-CoA synthetase (ACS1), play important roles in C. neoformans infecti...

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Detalles Bibliográficos
Autores principales: Alden, Katy M., Jezewski, Andrew J., Beattie, Sarah R., Fox, David, Krysan, Damian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426453/
https://www.ncbi.nlm.nih.gov/pubmed/35766403
http://dx.doi.org/10.1128/mbio.01279-22