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Continuous theta burst stimulation over left supplementary motor area facilitates auditory-vocal integration in individuals with Parkinson’s disease

Accumulating evidence suggests that impairment in auditory-vocal integration characterized by abnormally enhanced vocal compensations for auditory feedback perturbations contributes to hypokinetic dysarthria in Parkinson’s disease (PD). However, treatment of this abnormality remains a challenge. The...

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Autores principales: Dai, Guangyan, Wang, Meng, Li, Yongxue, Guo, Zhiqiang, Jones, Jeffery A., Li, Tingni, Chang, Yichen, Wang, Emily Q., Chen, Ling, Liu, Peng, Chen, Xi, Liu, Hanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426458/
https://www.ncbi.nlm.nih.gov/pubmed/36051304
http://dx.doi.org/10.3389/fnagi.2022.948696
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author Dai, Guangyan
Wang, Meng
Li, Yongxue
Guo, Zhiqiang
Jones, Jeffery A.
Li, Tingni
Chang, Yichen
Wang, Emily Q.
Chen, Ling
Liu, Peng
Chen, Xi
Liu, Hanjun
author_facet Dai, Guangyan
Wang, Meng
Li, Yongxue
Guo, Zhiqiang
Jones, Jeffery A.
Li, Tingni
Chang, Yichen
Wang, Emily Q.
Chen, Ling
Liu, Peng
Chen, Xi
Liu, Hanjun
author_sort Dai, Guangyan
collection PubMed
description Accumulating evidence suggests that impairment in auditory-vocal integration characterized by abnormally enhanced vocal compensations for auditory feedback perturbations contributes to hypokinetic dysarthria in Parkinson’s disease (PD). However, treatment of this abnormality remains a challenge. The present study examined whether abnormalities in auditory-motor integration for vocal pitch regulation in PD can be modulated by neuronavigated continuous theta burst stimulation (c-TBS) over the left supplementary motor area (SMA). After receiving active or sham c-TBS over left SMA, 16 individuals with PD vocalized vowel sounds while hearing their own voice unexpectedly pitch-shifted two semitones upward or downward. A group of pairwise-matched healthy participants was recruited as controls. Their vocal responses and event-related potentials (ERPs) were measured and compared across the conditions. The results showed that applying c-TBS over left SMA led to smaller vocal responses paralleled by smaller P1 and P2 responses and larger N1 responses in individuals with PD. Major neural generators of reduced P2 responses were located in the right inferior and medial frontal gyrus, pre- and post-central gyrus, and insula. Moreover, suppressed vocal compensations were predicted by reduced P2 amplitudes and enhanced N1 amplitudes. Notably, abnormally enhanced vocal and P2 responses in individuals with PD were normalized by c-TBS over left SMA when compared to healthy controls. Our results provide the first causal evidence that abnormalities in auditory-motor control of vocal pitch production in PD can be modulated by c-TBS over left SMA, suggesting that it may be a promising non-invasive treatment for speech motor disorders in PD.
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spelling pubmed-94264582022-08-31 Continuous theta burst stimulation over left supplementary motor area facilitates auditory-vocal integration in individuals with Parkinson’s disease Dai, Guangyan Wang, Meng Li, Yongxue Guo, Zhiqiang Jones, Jeffery A. Li, Tingni Chang, Yichen Wang, Emily Q. Chen, Ling Liu, Peng Chen, Xi Liu, Hanjun Front Aging Neurosci Neuroscience Accumulating evidence suggests that impairment in auditory-vocal integration characterized by abnormally enhanced vocal compensations for auditory feedback perturbations contributes to hypokinetic dysarthria in Parkinson’s disease (PD). However, treatment of this abnormality remains a challenge. The present study examined whether abnormalities in auditory-motor integration for vocal pitch regulation in PD can be modulated by neuronavigated continuous theta burst stimulation (c-TBS) over the left supplementary motor area (SMA). After receiving active or sham c-TBS over left SMA, 16 individuals with PD vocalized vowel sounds while hearing their own voice unexpectedly pitch-shifted two semitones upward or downward. A group of pairwise-matched healthy participants was recruited as controls. Their vocal responses and event-related potentials (ERPs) were measured and compared across the conditions. The results showed that applying c-TBS over left SMA led to smaller vocal responses paralleled by smaller P1 and P2 responses and larger N1 responses in individuals with PD. Major neural generators of reduced P2 responses were located in the right inferior and medial frontal gyrus, pre- and post-central gyrus, and insula. Moreover, suppressed vocal compensations were predicted by reduced P2 amplitudes and enhanced N1 amplitudes. Notably, abnormally enhanced vocal and P2 responses in individuals with PD were normalized by c-TBS over left SMA when compared to healthy controls. Our results provide the first causal evidence that abnormalities in auditory-motor control of vocal pitch production in PD can be modulated by c-TBS over left SMA, suggesting that it may be a promising non-invasive treatment for speech motor disorders in PD. Frontiers Media S.A. 2022-08-16 /pmc/articles/PMC9426458/ /pubmed/36051304 http://dx.doi.org/10.3389/fnagi.2022.948696 Text en Copyright © 2022 Dai, Wang, Li, Guo, Jones, Li, Chang, Wang, Chen, Liu, Chen and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Dai, Guangyan
Wang, Meng
Li, Yongxue
Guo, Zhiqiang
Jones, Jeffery A.
Li, Tingni
Chang, Yichen
Wang, Emily Q.
Chen, Ling
Liu, Peng
Chen, Xi
Liu, Hanjun
Continuous theta burst stimulation over left supplementary motor area facilitates auditory-vocal integration in individuals with Parkinson’s disease
title Continuous theta burst stimulation over left supplementary motor area facilitates auditory-vocal integration in individuals with Parkinson’s disease
title_full Continuous theta burst stimulation over left supplementary motor area facilitates auditory-vocal integration in individuals with Parkinson’s disease
title_fullStr Continuous theta burst stimulation over left supplementary motor area facilitates auditory-vocal integration in individuals with Parkinson’s disease
title_full_unstemmed Continuous theta burst stimulation over left supplementary motor area facilitates auditory-vocal integration in individuals with Parkinson’s disease
title_short Continuous theta burst stimulation over left supplementary motor area facilitates auditory-vocal integration in individuals with Parkinson’s disease
title_sort continuous theta burst stimulation over left supplementary motor area facilitates auditory-vocal integration in individuals with parkinson’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426458/
https://www.ncbi.nlm.nih.gov/pubmed/36051304
http://dx.doi.org/10.3389/fnagi.2022.948696
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